ANTI-TFYY1 (NF1)
- CAS No.
- Chemical Name:
- ANTI-TFYY1 (NF1)
- Synonyms
- Anti-WSS;Anti-VRNF;Anti-NFNS;Neurofibromin;ANTI-TFYY1 (NF1);Anti-DKFZp686J1293;Monoclonal Anti-WSS;Monoclonal Anti-NFNS;Monoclonal Anti-VRNF;Monoclonal Anti-neurofibromin 1
- CBNumber:
- CB1713534
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD02264160
- MOL File:
- Mol file
ANTI-TFYY1 (NF1) price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SAB4501977 | Anti-NF1 antibody produced in rabbit affinity isolated antibody | 100μG | $506 | 2024-03-01 | Buy | |
| Sigma-Aldrich | AMAB91741 | Monoclonal Anti-NF1 antibody produced in mouse Prestige Antibodies? Powered by Atlas Antibodies, clone CL11773, purified immunoglobulin, buffered aqueous glycerol solution | 100μL | $547 | 2024-03-01 | Buy | |
| Sigma-Aldrich | AMAB91741 | Monoclonal Anti-NF1 antibody produced in mouse Prestige Antibodies? Powered by Atlas Antibodies, clone CL11773, purified immunoglobulin, buffered aqueous glycerol solution | 25μL | $282 | 2023-06-20 | Buy | |
| Sigma-Aldrich | SAB4200499 | Monoclonal Anti-NF1 antibody produced in mouse clone NF1-333, tissue culture supernatant | 200μL | $437 | 2022-05-15 | Buy |
ANTI-TFYY1 (NF1) Chemical Properties,Uses,Production
Uses
Monoclonal Anti-NF1 antibody produced in mouse has been used in western blotting. It may be suitable for use in flow cytometry.
General Description
Monoclonal Anti-NF1 (mouse IgM isotype) is derived from the hybridoma NF1-333 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. Neurofibromin 1 (NF1) gene is located at chromosome 17q11.2. It is predominantly expressed in neurons, Schwann cells, oligodendrocytes, astrocytes and leukocytes. NF1 has two potentially functional domains; Ras GTPase activating protein (RasGAP)and phosphatidylinositol-transfer protein.
Biochem/physiol Actions
NF1 acts as a negative regulator of the p21-Ras/mitogen-activated protein kinase (MAPK) pathway as well as a tumor suppressor gene. Mutations in the neurofibromin 1 (NF1) gene is implicated in Neurofibromatosis type 1 (NF1) gene also known as von Recklinghausen peripheral or classical neurofibromatosis, is one of the most common autosomal dominant diseases. Consistent with a central role for neurofibromin in cellular function, recent cancer genome sequencing studies have found that somatic NF1 gene mutations occur not only in association with NF1, but also in a number of other common cancers. A variety of benign and malignant tumours are associated with NF1 and all involve tumorigenesis of neural crest-derived cells.