CAY10702
- CAS No.
- 1830320-32-5
- Chemical Name:
- CAY10702
- Synonyms
- RB394;CAY10702;α-ethyl-4-[[[[4-methoxy-2-(trifluoromethyl)phenyl]methyl]amino]carbonyl]-benzenepropanoicacid;Benzenepropanoic acid, α-ethyl-4-[[[[4-methoxy-2-(trifluoromethyl)phenyl]methyl]amino]carbonyl]-
- CBNumber:
- CB13152585
- Molecular Formula:
- C21H22F3NO4
- Molecular Weight:
- 409.399
- MDL Number:
- MOL File:
- 1830320-32-5.mol
CAY10702 price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18909 | CAY10702 ≥98% | 1830320-32-5 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 18909 | CAY10702 ≥98% | 1830320-32-5 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 18909 | CAY10702 ≥98% | 1830320-32-5 | 10mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 18909 | CAY10702 ≥98% | 1830320-32-5 | 25mg | $533 | 2024-03-01 | Buy |
| ApexBio Technology | C5671 | RB394 | 1830320-32-5 | 25mg | $608 | 2021-12-16 | Buy |
CAY10702 Chemical Properties,Uses,Production
Biological Activity
rb394 is an orally bioavailable and dual modulator of soluble epoxide hydrolase (seh) and pparγ [1].soluble epoxide hydrolase (seh) is a bifunctional enzyme involved in the in vivo metabolism of endogenous lipid epoxides. the seh is abundantly expressed in adipose tissue. seh is an enzyme of the arachidonic acid cascade, promoting the hydrolysis of cytochrome p450 derived epoxyeicosatrienoic acids (eets). endothelial cell-derived eets activate calcium-activated potassium channels on smooth muscle cells, leading to hyperpolarization and vascular relaxation. pparγ, a member of the ppar nuclear receptor family, plays an important role in adipogenesis, regulation of lipid metabolism and glucose homeostasis, and anti-inflammatory processes [1].rb394 inhibited the activity of seh with an ic50 of 0.33 μm and activated pparγ with an ec50 of 0.3 μm. rb394 was inactive at pparδ and showed 29% activation of pparαat 10 μm. in mice, treatment with 30 mg/kg rb394 in drinking water for two weeks resulted in a final plasma concentration of ~3 μm. rb394 upregulated the pparγ target genes, as well as pparα and pparδ in mouse livers [1].
References
[1] blocher r, lamers c, wittmann s k, et al. n-benzylbenzamides: a novel merged scaffold for orally available dual soluble epoxide hydrolase/peroxisome proliferator-activated receptor γ modulators[j]. journal of medicinal chemistry, 2015, 59(1): 61-81.
CAY10702 Preparation Products And Raw materials
Raw materials
Preparation Products
CAY10702 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11974 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6251 | 58 |
| Supplier | Advantage |
|---|---|
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
| MedBioPharmaceutical Technology Inc | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| ApexBio Technology | 58 |