sodiuM (R)-(Methylsulfonyl)(2-(4-(((trifluoroMethyl)sulfonyl)oxy)phenyl)propanoyl)aMide
- CAS No.
- 865625-56-5
- Chemical Name:
- sodiuM (R)-(Methylsulfonyl)(2-(4-(((trifluoroMethyl)sulfonyl)oxy)phenyl)propanoyl)aMide
- Synonyms
- DF2156;DF 2156;DF2156A;DF-2156;DF-2156A;DF 2156A;sodiuM (R)-(Methylsulfonyl)(2-(4-(((trifluoroMethyl)sulfonyl)oxy)phenyl)propanoyl)aMide
- CBNumber:
- CB12598858
- Molecular Formula:
- C11H11F3NNaO6S2
- Molecular Weight:
- 397.3231196
- MDL Number:
- MFCD22419381
- MOL File:
- 865625-56-5.mol
SAFETY
Risk and Safety Statements
| Signal word | Warning |
|---|---|
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
sodiuM (R)-(Methylsulfonyl)(2-(4-(((trifluoroMethyl)sulfonyl)oxy)phenyl)propanoyl)aMide Chemical Properties,Uses,Production
Uses
Ladarixin Sodium is a a dual CXCR1/2 inhibitor. It has therapeutic potential for treating type I diabetes and various melanoma.
in vivo
Ladarixin (10 mg/kg; p.o. once a day) reduces allergic airway inflammation in a model of single OVA exposure. Ladarixin reduces allergic airway inflammation, remodeling, and bronchial hyperreactivity in a model of chronic OVA exposure[1].
Ladarixin (10 mg/kg; p.o. once a day for 8 days) reduces pulmonary inflammation and fibrosis induced by bleomycin in mice[1].
Ladarixin (10 mg/kg; p.o. once a day for 3 days) protects mice from cigarette smoke-induced exacerbation of influenza-A infection[1].
Ladarixin is also effective in decreasing CXCL8-induced polymorphonuclear leukocyte infiltration in several animal models without a significant dose-related reduction in systemic neutrophil counts[2].
| Animal Model: | Mice (cigarette smoke-induced exacerbation of Influenza-A infection model)[1] |
| Dosage: | 10 mg/kg |
| Administration: | P.o. once a day at days 2, 3 and 4 post-infection |
| Result: | Significantly attenuated the exacerbation in lethality and respiratory changes noted in CSFlu group. |
IC 50
CXCR1; CXCR2
sodiuM (R)-(Methylsulfonyl)(2-(4-(((trifluoroMethyl)sulfonyl)oxy)phenyl)propanoyl)aMide Preparation Products And Raw materials
Raw materials
Preparation Products
sodiuM (R)-(Methylsulfonyl)(2-(4-(((trifluoroMethyl)sulfonyl)oxy)phenyl)propanoyl)aMide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32286 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19904 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 4998 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 21356 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12000 | 58 |
View Lastest Price from sodiuM (R)-(Methylsulfonyl)(2-(4-(((trifluoroMethyl)sulfonyl)oxy)phenyl)propanoyl)aMide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | Ladarixin Sodium
865625-56-5
|
US $177.00-916.00 / mg | 10g | TargetMol Chemicals Inc. |
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- Ladarixin Sodium
865625-56-5
- US $177.00-916.00 / mg
- TargetMol Chemicals Inc.