Biological Activity

Intronist at B is a potent inhibitor of the self-splicing group IIB intron, a mitochondrial RNA tertiary structure necessary for respiration in fungi, yeast and plants, but not found in vertebrates. Intronist at B was found to have antifungal activity comparable to th at of amphotericin B in inhibiting growth of the Candida parapsilosis. It did not inhibit spliceosomal processing, group I intron splicing or splicing of group II introns from subclasses other than subclass IIB and was not toxic to human cells.