2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-
- CAS No.
- 2226664-93-1
- Chemical Name:
- 2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-
- Synonyms
- A3051;Ky19382;KY19382(A3051);KY19382, 10 mM in DMSO;5',6'-Dichloro-3-(methoxyimino)-[2,3'-biindolinylidene]-2'-one;2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-;2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382;Glycogen synthase kinase 3,Beta catenin,β-catenin,GSK-3,KY 19382,inhibit,Wnt,Inhibitor,KY-19382,A 3051,KY19382,A-3051,Glycogen synthase kinase-3
- CBNumber:
- CB08094272
- Molecular Formula:
- C17H11Cl2N3O2
- Molecular Weight:
- 360.19
- MDL Number:
- MOL File:
- 2226664-93-1.mol
2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0134890 | KY19382 98.04% | 2226664-93-1 | 5mg | $400 | 2021-12-16 | Buy |
ChemScene | CS-0134890 | KY19382 98.04% | 2226664-93-1 | 10mg | $680 | 2021-12-16 | Buy |
ChemScene | CS-0134890 | KY19382 98.04% | 2226664-93-1 | 50mg | $1900 | 2021-12-16 | Buy |
ChemScene | CS-0134890 | KY19382 98.04% | 2226664-93-1 | 100mg | $2900 | 2021-12-16 | Buy |
DC Chemicals | DC40570 | KY19382 >98% | 2226664-93-1 | 100mg | $750 | 2021-12-16 | Buy |
2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- Chemical Properties,Uses,Production
Uses
KY 19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β.
in vivo
KY19382 (0.1 mg/kg; i.p. once daily for 2 weeks) delays growth plate senescence in older mice and promotes growth plate maturation in rapidly growing young mice[1].
KY19382 (0.1 mg/kg; i.p. once daily for 10 weeks) significantly increases the length of tibiae in mice[1].
KY19382 (5 mg/kg; i.p.) displays a relatively favorable bioavailability (F=16.74%), showing half-life of 16.20 h and an exposure level of 6,555.79 ng?h/ml[1].
KY19382 (A3051) (25 mg/kg; p.o. once daily for 16 weeks) shows reduction in adipocyte size and anti-inflammatory effects[2].
A3051 (25 mg/kg; p.o. once daily for 5 days) reduces fasting glucose in mice[2].
A3051 (25 mg/kg; p.o. once daily for 3 weeks) reduces the hepatosteatosis in mice[2].
Animal Model: | C57BL/6 male mice (7-weeks-old or 3-weeks-old)[1] |
Dosage: | 0.1 mg/kg |
Administration: | I.p. once daily for 2 weeks |
Result: | Increased nuclear β-catenin in the growth plate chondrocytes dramatically. Elevated the height of each growth plate zone and BrdU-positive cells. Did not affect the cartilage resorption of rapidly growing young mice. |
Animal Model: | SD male rats[1] |
Dosage: | 1 mg/kg for i.v. and 5 mg/kg for i.p. (Pharmacokinetic Analysis) |
Administration: | I.v. and i.p. administration |
Result: | I.v.: t1/2=3.33 h; AUC=7832.81 ng?h/mL; CL=0.12 L/h/kg. I.p.: t1/2=16.20 h; F=16.74%; Cmax=463.37 ng/mL. |
IC 50
CXXC5-DVL: 19 nM (IC50); GSK3β: 10 nM (IC50)
2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- Preparation Products And Raw materials
Raw materials
Preparation Products
2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32291 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
TargetMol Chemicals Inc. | support@targetmol.com | United States | 38669 | 58 | |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
DC Chemicals | 021-8447131 13564518121 | doncunbiosci@gmail.com | China | 512 | 58 |
Wuhan HengHeDa Pharm Co., Ltd. | 027-84888681 18086046872 | hhdpharm@hotmail.com | China | 105 | 55 |
Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 6448 | 55 |