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ChemicalBook >> CAS DataBase List >>2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-

2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-

CAS No.
2226664-93-1
Chemical Name:
2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-
Synonyms
A3051;Ky19382;KY19382（A3051）;KY19382, 10 mM in DMSO;5',6'-Dichloro-3-(methoxyimino)-[2,3'-biindolinylidene]-2'-one;2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-;2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382;Glycogen synthase kinase 3,Beta catenin,β-catenin,GSK-3,KY 19382,inhibit,Wnt,Inhibitor,KY-19382,A 3051,KY19382,A-3051,Glycogen synthase kinase-3
CBNumber:
CB08094272
Molecular Formula:
C17H11Cl2N3O2
Molecular Weight:
360.19
MDL Number:
MOL File:
2226664-93-1.mol
Last updated:2025-06-05 11:18:57

2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- Properties

Density 1.58±0.1 g/cm3(Predicted)
pka 8.80±0.20(Predicted)
form Solid
color Brown to reddish brown

2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0134890 KY19382 98.04% 2226664-93-1 5mg $400 2021-12-16 Buy
ChemScene CS-0134890 KY19382 98.04% 2226664-93-1 10mg $680 2021-12-16 Buy
ChemScene CS-0134890 KY19382 98.04% 2226664-93-1 50mg $1900 2021-12-16 Buy
ChemScene CS-0134890 KY19382 98.04% 2226664-93-1 100mg $2900 2021-12-16 Buy
DC Chemicals DC40570 KY19382 >98% 2226664-93-1 100mg $750 2021-12-16 Buy
Product number Packaging Price Buy
CS-0134890 5mg $400 Buy
CS-0134890 10mg $680 Buy
CS-0134890 50mg $1900 Buy
CS-0134890 100mg $2900 Buy
DC40570 100mg $750 Buy

2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- Chemical Properties,Uses,Production

Uses

KY 19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β.

in vivo

KY19382 (0.1 mg/kg; i.p. once daily for 2 weeks) delays growth plate senescence in older mice and promotes growth plate maturation in rapidly growing young mice[1].
KY19382 (0.1 mg/kg; i.p. once daily for 10 weeks) significantly increases the length of tibiae in mice[1].
KY19382 (5 mg/kg; i.p.) displays a relatively favorable bioavailability (F=16.74%), showing half-life of 16.20 h and an exposure level of 6,555.79 ng?h/ml[1].
KY19382 (A3051) (25 mg/kg; p.o. once daily for 16 weeks) shows reduction in adipocyte size and anti-inflammatory effects[2].
A3051 (25 mg/kg; p.o. once daily for 5 days) reduces fasting glucose in mice[2].
A3051 (25 mg/kg; p.o. once daily for 3 weeks) reduces the hepatosteatosis in mice[2].

Animal Model:C57BL/6 male mice (7-weeks-old or 3-weeks-old)[1]
Dosage:0.1 mg/kg
Administration:I.p. once daily for 2 weeks
Result:Increased nuclear β-catenin in the growth plate chondrocytes dramatically.
Elevated the height of each growth plate zone and BrdU-positive cells.
Did not affect the cartilage resorption of rapidly growing young mice.
Animal Model:SD male rats[1]
Dosage:1 mg/kg for i.v. and 5 mg/kg for i.p. (Pharmacokinetic Analysis)
Administration:I.v. and i.p. administration
Result:I.v.: t1/2=3.33 h; AUC=7832.81 ng?h/mL; CL=0.12 L/h/kg.
I.p.: t1/2=16.20 h; F=16.74%; Cmax=463.37 ng/mL.

IC 50

CXXC5-DVL: 19 nM (IC50); GSK3β: 10 nM (IC50)

2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- Preparation Products And Raw materials

Raw materials

Preparation Products

2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- Suppliers

Global( 28)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 32291 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38669 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
DC Chemicals 021-8447131 13564518121 doncunbiosci@gmail.com China 512 58
Wuhan HengHeDa Pharm Co., Ltd. 027-84888681 18086046872 hhdpharm@hotmail.com China 105 55
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71826 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 6448 55

View Lastest Price from 2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
KY19382 pictures 2025-06-05 KY19382
2226664-93-1
 US $100.00-369.00 / mg 98.06% 10g TargetMol Chemicals Inc.
  • KY19382 pictures
  • KY19382
    2226664-93-1
  • US $100.00-369.00 / mg
  • 98.06%
  • TargetMol Chemicals Inc.
2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- Ky19382 A3051 2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382 Glycogen synthase kinase 3,Beta catenin,β-catenin,GSK-3,KY 19382,inhibit,Wnt,Inhibitor,KY-19382,A 3051,KY19382,A-3051,Glycogen synthase kinase-3 5',6'-Dichloro-3-(methoxyimino)-[2,3'-biindolinylidene]-2'-one KY19382（A3051） KY19382, 10 mM in DMSO 2226664-93-1