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ChemicalBook >> CAS DataBase List >>SM16

SM16

CAS No.
614749-78-9
Chemical Name:
SM16
Synonyms
SM16;CS-2835;SM-16,TGF-β Receptor,Inhibitor,inhibit,SM 16,Transforming growth factor beta receptors,SM16;4-[4-(1,3-Benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide;4-[5-(2H-1,3-benzodioxol-5-yl)-4-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide;Bicyclo[2.2.2]octane-1-carboxamide, 4-[4-(1,3-benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]-
CBNumber:
CB04656566
Molecular Formula:
C25H26N4O3
Molecular Weight:
430.5
MDL Number:
MOL File:
614749-78-9.mol
Last updated:2024-11-19 20:33:22

SM16 Properties

Boiling point 691.3±55.0 °C(Predicted)
Density 1.354±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:65.0(Max Conc. mg/mL);150.99(Max Conc. mM)
form A solid
pka 11.23±0.10(Predicted)
color White to off-white

SM16 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Tocris 6245 SM16 ≥98%(HPLC) 614749-78-9 10 $300 2021-12-16 Buy
ChemScene CS-0042167 SM16 99.96% 614749-78-9 50mg $550 2021-12-16 Buy
ChemScene CS-0042167 SM16 99.96% 614749-78-9 10mg $190 2021-12-16 Buy
ChemScene CS-0042167 SM16 99.96% 614749-78-9 5mg $110 2021-12-16 Buy
ChemScene CS-0042167 SM16 99.96% 614749-78-9 100mg $950 2021-12-16 Buy
Product number Packaging Price Buy
6245 10 $300 Buy
CS-0042167 50mg $550 Buy
CS-0042167 10mg $190 Buy
CS-0042167 5mg $110 Buy
CS-0042167 100mg $950 Buy

SM16 Chemical Properties,Uses,Production

Biological Activity

SM 16 is an ALK5/ALK4 kinase inhibitor with Ki values of 10 and 1.5 nM, respectively.

in vivo

SM 16 penetrates tumor cells in vivo , suppressing tumor phosphorylated Smad2/3 levels for at least 3 h following treatment of tumor-bearing mice with a single ip bolus of 20 mg/kg SM 16. The growth of established AB12 tumors is significantly inhibited by 5 mg/kg/d SM 16 (P<0.001) delivered via sc miniosmotic pumps over 28 days.

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target

Ki: ALK5 (10 nM), ALK4 (1.5 nM)

storage

Store at -20°C

SM16 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 41)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32965 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30236 58
Chemia Biotechnology（Shanghai） Co., Ltd 		+8613816753574 info@chemia-pharm.com CHINA 311 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52924 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3466 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7787 56

View Lastest Price from SM16 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SM 16 pictures 2024-11-19 SM 16
614749-78-9
 US $38.00-155.00 / mg 99.81% 10g TargetMol Chemicals Inc.
  • SM 16 pictures
  • SM 16
    614749-78-9
  • US $38.00-155.00 / mg
  • 99.81%
  • TargetMol Chemicals Inc.
4-[4-(1,3-Benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide CS-2835 Bicyclo[2.2.2]octane-1-carboxamide, 4-[4-(1,3-benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]- SM16 SM-16,TGF-β Receptor,Inhibitor,inhibit,SM 16,Transforming growth factor beta receptors,SM16 4-[5-(2H-1,3-benzodioxol-5-yl)-4-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide 614749-78-9