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ChemicalBook >> CAS DataBase List >>6-[2-(3,4-diethoxyphenyl)-1,3-thiazol-4-yl]pyridine-2-carboxylic acid

6-[2-(3,4-diethoxyphenyl)-1,3-thiazol-4-yl]pyridine-2-carboxylic acid

CAS No.
145739-56-6
Chemical Name:
6-[2-(3,4-diethoxyphenyl)-1,3-thiazol-4-yl]pyridine-2-carboxylic acid
Synonyms
OPC-6535;TETOMILAST;-(4-hydroxyphenyl)acrylaldehyde;Tetomilast (Synonyms: OPC-6535);6-(2-(3,4-diethoxyphenyl)thiazol-4-yl)picolinic acid;6-[2-(3,4-diethoxyphenyl)-thiazole-4-yl]pyridine-2-carboxylic acid;2-Pyridinecarboxylic acid, 6-[2-(3,4-diethoxyphenyl)-4-thiazolyl]-;6-[2-(3,4-Diethoxy-phenyl)-thiazol-4-yl]-pyridine-2-carboxylic acid;6-[2-(3,4-diethoxyphenyl)-1,3-thiazol-4-yl]pyridine-2-carboxylic acid
CBNumber:
CB01258549
Molecular Formula:
C19H18N2O4S
Molecular Weight:
370.42
MDL Number:
MOL File:
145739-56-6.mol
MSDS File:
SDS
Last updated:2025-04-18 09:51:23

6-[2-(3,4-diethoxyphenyl)-1,3-thiazol-4-yl]pyridine-2-carboxylic acid Properties

Boiling point 598.6±60.0 °C(Predicted)
Density 1.279±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka 3.28±0.10(Predicted)
form Solid
color White to off-white
FDA UNII S6RXB5KF56

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

6-[2-(3,4-diethoxyphenyl)-1,3-thiazol-4-yl]pyridine-2-carboxylic acid price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation CHM1014659 6-[2-(3,4-DIETHOXYPHENYL)-1,3-THIAZOL-4-YL]PYRIDINE-2-CARBOXYLIC ACID 95.00% 145739-56-6 5MG $505.42 2021-12-16 Buy
Chemenu CM177913 6-(2-(3,4-diethoxyphenyl)thiazol-4-yl)picolinicacid 95% 145739-56-6 1g $1222 2021-12-16 Buy
Crysdot CD11253526 6-(2-(3,4-Diethoxyphenyl)thiazol-4-yl)picolinicacid 95+% 145739-56-6 1g $1297 2021-12-16 Buy
Crysdot CD11253526 6-(2-(3,4-Diethoxyphenyl)thiazol-4-yl)picolinicacid 95+% 145739-56-6 5g $3120 2021-12-16 Buy
Crysdot CD11253526 6-(2-(3,4-Diethoxyphenyl)thiazol-4-yl)picolinicacid 95+% 145739-56-6 10g $4683 2021-12-16 Buy
Product number Packaging Price Buy
CHM1014659 5MG $505.42 Buy
CM177913 1g $1222 Buy
CD11253526 1g $1297 Buy
CD11253526 5g $3120 Buy
CD11253526 10g $4683 Buy

6-[2-(3,4-diethoxyphenyl)-1,3-thiazol-4-yl]pyridine-2-carboxylic acid Chemical Properties,Uses,Production

Uses

Tetomilast (OPC-6535) is a PDE4 inhibitor with potential for the research of inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD).

IC 50

PDE4

References

[1] Ichikawa H, Okamoto S, Kamada N, et al. Tetomilast suppressed production of proinflammatory cytokines from human monocytes and ameliorated chronic colitis in IL-10-deficient mice. Inflamm Bowel Dis. 2008;14(11):1483-1490. DOI:10.1002/ibd.20524

298692-34-9
60759-00-4
145739-56-6
Synthesis of 6-[2-(3,4-diethoxyphenyl)-1,3-thiazol-4-yl]pyridine-2-carboxylic acid from 2-Pyridinecarboxylic acid, 6-(chloroacetyl)- (9CI) and BenzenecarbothioaMide, 3,4-diethoxy-

6-[2-(3,4-diethoxyphenyl)-1,3-thiazol-4-yl]pyridine-2-carboxylic acid Preparation Products And Raw materials

6-[2-(3,4-diethoxyphenyl)-1,3-thiazol-4-yl]pyridine-2-carboxylic acid Suppliers

Global( 28)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29807 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490 info@gihichemicals.com China 49980 58
Zhengzhou Anbu Chem Co.,Ltd 		+86-0371-88006763; +8615988602810 sales@anbuchem.com China 2998 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+86-18621343501; +undefined18621343501 product@acmec-e.com China 33338 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580 cooperation@kean-chem.com China 40066 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2922 55
Chembest Research Laboratories Limited +86-21-20908456 sales@BioChemBest.com China 6005 61
Heterochem 027-88041443 13072715837 sales@hetero-chem.com China 696 58
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10266 58

View Lastest Price from 6-[2-(3,4-diethoxyphenyl)-1,3-thiazol-4-yl]pyridine-2-carboxylic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TETOMILAST pictures 2019-12-20 TETOMILAST
145739-56-6
 US $2.00 / KG 1KG 98%min ask Career Henan Chemical Co
  • TETOMILAST pictures
  • TETOMILAST
    145739-56-6
  • US $2.00 / KG
  • 98%min
  • Career Henan Chemical Co
-(4-hydroxyphenyl)acrylaldehyde 6-[2-(3,4-diethoxyphenyl)-1,3-thiazol-4-yl]pyridine-2-carboxylic acid 6-(2-(3,4-diethoxyphenyl)thiazol-4-yl)picolinic acid 6-[2-(3,4-Diethoxy-phenyl)-thiazol-4-yl]-pyridine-2-carboxylic acid TETOMILAST 2-Pyridinecarboxylic acid, 6-[2-(3,4-diethoxyphenyl)-4-thiazolyl]- 6-[2-(3,4-diethoxyphenyl)-thiazole-4-yl]pyridine-2-carboxylic acid Tetomilast (Synonyms: OPC-6535) OPC-6535 145739-56-6