BAW2881
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- CAS號(hào):
- 861875-60-7
- 英文名:
- NVP-BAW2881
- 英文別名:
- CS-2238;BAW2881;NVP-BAW2881;BAW2881 (NVP-BAW2881);NVP-BAW2881;NVP-BAW-2881;;NVP-BAW 2881;6-((2-aminopyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide;1-Naphthalenecarboxamide, 6-[(2-amino-4-pyrimidinyl)oxy]-N-[3-(trifluoromethyl)phenyl]-;6-(2-amino-pyrimidin-4-yloxy)naphthalene-1-carboxylic acid (3-trifluoromethyl phenyl)amide;NVPBAW2881,inhibit,BAW 2881,NVP BAW2881,Vascular endothelial growth factor receptor,VEGFR,Inhibitor,NVP-BAW2881,BAW-2881,NVP-BAW-2881
- 中文名:
- BAW2881
- 中文別名:
- 化合物BAW2881;6-((2-氨基-4-嘧啶基)氧基)-N-(3-(三氟甲基)苯基)-1-萘甲酰胺
- CBNumber:
- CB93133229
- 分子式:
- C22H15F3N4O2
- 分子量:
- 424.38
- MOL File:
- 861875-60-7.mol
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BAW2881化學(xué)性質(zhì)
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儲(chǔ)存條件:
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Store at -20°C
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溶解度:
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≥42.4 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
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形態(tài):
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solid
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顏色:
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White to off-white
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BAW2881性質(zhì)、用途與生產(chǎn)工藝
BAW2881 (NVP-BAW2881)是一種新型的VEGFR酪氨酸激酶抑制劑。在1.0-4.3 nM濃度下能有效地抑制VEGFR1-3；在45-72 nM的濃度下，抑制PDGFRβ, c-Kit和RET (c-RET)。
| Target | Value |
hVEGFR2
(Cell-free assay)
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9 nM
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C-Raf-1
(Cell-free assay)
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24 nM
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B-RAFV599E
(Cell-free assay)
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76 nM
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c-Abl
(Cell-free assay)
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99 nM
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mVEGF2
(Cell-free assay)
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165 nM
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體外實(shí)驗(yàn)證明NVP-BAW2881能夠抑制人臍靜脈內(nèi)皮細(xì)胞和淋巴管內(nèi)皮細(xì)胞的增殖、遷移以及小管生成。
NVP-BAW2881能夠靶向鼠源、豬源和人源VEGFR2的酪氨酸激酶區(qū)域。它能通過口服或局部施用，但還未在人類中進(jìn)行試驗(yàn)。在VEGF-A轉(zhuǎn)基因小鼠的體內(nèi)試驗(yàn)中，口服或局部NVP-BAW2881給藥能減少耳部皮膚的類似牛皮蘚的炎癥。處理過的小鼠的皮膚損傷處會(huì)減少白細(xì)胞浸潤(rùn)、減少表皮增生、正常表皮角化細(xì)胞分化以及較少的血管異常。NVP-BAW2881處理過的小鼠的血管變小、數(shù)量減少。相較于對(duì)照組，實(shí)驗(yàn)組小鼠的耳腫脹、皮膚炎癥、淋巴結(jié)腫大、皮膚紅斑得到改善。雖然兩種給藥途徑都有效（口服和局部施用），但全身性用藥比局部給藥更為強(qiáng)效。局部施用NVP-BAW2881在小鼠和家豬皮膚中，能減少VEGF-A誘導(dǎo)的血管通透性。
BAW2881
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2024/11/08 | HY-100394 | BAW2881
NVP-BAW2881 | 861875-60-7 | 2mg | 500元 |
| 2024/11/08 | HY-100394 | BAW2881
NVP-BAW2881 | 861875-60-7 | 10mM * 1mLin DMSO | 747元 |
861875-60-7, BAW2881 相關(guān)搜索:
- 抑制劑
- 藥靶配體
- 標(biāo)準(zhǔn)品
- 6-((2-氨基-4-嘧啶基)氧基)-N-(3-(三氟甲基)苯基)-1-萘甲酰胺
- 化合物BAW2881
- 861875-60-7
- NVPBAW2881,inhibit,BAW 2881,NVP BAW2881,Vascular endothelial growth factor receptor,VEGFR,Inhibitor,NVP-BAW2881,BAW-2881,NVP-BAW-2881
- 1-Naphthalenecarboxamide, 6-[(2-amino-4-pyrimidinyl)oxy]-N-[3-(trifluoromethyl)phenyl]-
- NVP-BAW2881;NVP-BAW-2881;;NVP-BAW 2881
- CS-2238
- 6-(2-amino-pyrimidin-4-yloxy)naphthalene-1-carboxylic acid (3-trifluoromethyl phenyl)amide
- 6-((2-aminopyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide
- BAW2881 (NVP-BAW2881)
- BAW2881
- NVP-BAW2881