氯德拉苯
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- CAS號:
- 111149-90-7
- 英文名:
- Declaben
- 英文別名:
- SC-39026;Declaben;Lodelaben;Lodelabenum;Lodelaben (SC-39026);Lodelabenum [inn-latin];Benzoic acid, 2-chloro-4-(1-hydroxyoctadecyl)-
- 中文名:
- 氯德拉苯
- 中文別名:
- 氯德拉苯;化合物 T11865;LODELABEN (SC-39026)
- CBNumber:
- CB91178428
- 分子式:
- C25H41ClO3
- 分子量:
- 425.04
- MOL File:
- 111149-90-7.mol
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氯德拉苯化學性質
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沸點:
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539.8±40.0 °C(Predicted)
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密度:
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1.038±0.06 g/cm3(Predicted)
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儲存條件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系數(shù)(pKa):
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3.09±0.25(Predicted)
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形態(tài):
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Solid
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顏色:
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White to off-white
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氯德拉苯性質、用途與生產工藝
Lodelaben 是一種人類嗜中性粒細胞彈性蛋白酶抑制劑,其 IC50 和 Ki 值分別 0.5 和 1.5 μM。
IC50: 0.5 μM (elastase)
Ki: 1.5 μM (elastase)
Lodelaben is a human neutrophil elastase inhibitor with an IC
50
and K
i
of 0.5 and 1.5 μM, respectively. Results indicate that the inhibition of human neutrophil elastase (HNE) by Lodelaben is non-competetive. Lodelaben is not inhibitory at 10 μM with the synthetic substrates or at 5 μM vith Azocoll. Pseudomonas aeruginosa elastase, a metallo-protease is not inhibited by Lodelaben. Cathepsin G activity, however, is inhibited by Lodelaben, with an IC
50
of approximately 2.5 μM, with Azocoll as substrate.
The mean pulmonary artery pressures of the saline/vehicle and saline/Lodelaben groups are similar, 16.4±1.1 and 17.4±0.9 mm Hg, respectively. Although, mean pulmonary artery pressure in the monocrotaline/vehicle group is 27.5±0.8 mm Hg, treatment of monocrotaline rats with Lodelaben results in significantly lower values (21.00±1.6 mm Hg, p<0.05). Saline/vehicle and saline/Lodelaben rats have only a small percentage of arteries muscularized at the alveolar wall level (1.9±1.4 and 0.4±0.4%, respectively). Treatment of monocrotaline-injected rats with Lodelaben results in a decreased percentage of alveolar wall arteries muscularized (10.0±3.6%).
氯德拉苯
上下游產品信息
上游原料
下游產品
更新日期 | 產品編號 | 產品名稱 | CAS編號 | 包裝 | 價格 |
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2024/11/08 | HY-100240 | Lodelaben | | 1 mg | 9800元 |
2023/03/20 | HY-100240 | 氯德拉苯 Lodelaben | 111149-90-7 | 5mg | 36000元 |
111149-90-7, 氯德拉苯 相關搜索:
- 抑制劑
- C25H41ClO3
- LODELABEN (SC-39026)
- 化合物 T11865
- 氯德拉苯
- 111149-90-7
- Lodelaben (SC-39026)
- SC-39026
- Lodelabenum [inn-latin]
- Lodelabenum
- Benzoic acid, 2-chloro-4-(1-hydroxyoctadecyl)-
- Lodelaben
- Declaben