SEC
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- CAS號:
- 1802997-81-4
- 英文名:
- 1H-Pyrazole-5-carboxylic acid, 1-[(2S)-3-(4-chlorophenoxy)-2-hydroxypropyl]-3-(4-methoxyphenyl)-, ethyl ester
- 英文別名:
- SEC;1H-Pyrazole-5-carboxylic acid, 1-[(2S)-3-(4-chlorophenoxy)-2-hydroxypropyl]-3-(4-methoxyphenyl)-, ethyl ester
- 中文名:
- SEC
- 中文別名:
- 金黃色葡萄球菌腸毒素C(SEC)ELISA試劑盒
- CBNumber:
- CB68108739
- 分子式:
- C22H23ClN2O5
- 分子量:
- 430.88
- MOL File:
- 1802997-81-4.mol
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SEC化學(xué)性質(zhì)
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沸點:
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627.7±55.0 °C(Predicted)
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密度:
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1.27±0.1 g/cm3(Predicted)
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酸度系數(shù)(pKa):
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13.31±0.20(Predicted)
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形態(tài):
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Oil
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顏色:
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Light yellow to yellow
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SEC性質(zhì)、用途與生產(chǎn)工藝
SEC 通過 AMPK/mTORC1/STAT3 信號通路誘導(dǎo) ANXA7 GTPase 的激活。SEC 選擇性的促進(jìn)癌細(xì)胞的凋亡,誘導(dǎo) ITGB4 核轉(zhuǎn)位,表達(dá)高水平 ITGB4。
SEC (20 μM) inhibits the cell migration of HEK 293T RKIP
?/?
cells and PC3 prostate cancer cells.
SEC (20 μM) significantly increases AMPK phosphorylation in PC3 cells, which is inverted by ANXA7 GTPase specific inhibitor ABO, indicating that activated ANXA7 with enhanced phosphorylation level promotes AMPK phosphorylation (
cell selectively
).
Cell Viability Assay
Cell Line:
|
HEK293T RKIP
?/?
cells.
[1]
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Concentration:
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20 μM.
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Incubation Time:
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24 h.
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Result:
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Suppressed HEK293T RKIP
?/?
cell migration while had no effect on HEK293T RKIP
+/+
cells.
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SEC (3 mg/kg/day or 18 mg/kg/day) suppresses metastasis in PC-3M-Luc orthotopic implantation nude mice model.
Animal Model:
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Luciferase-labeled PC-3M-Luc cells (2×10
6
per 50 μL sterile HBSS
?/?
) are orthotopically inoculated into the prostates of 8-week-old nude mice.
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Dosage:
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3 mg/kg/day or 18 mg/kg/day.
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Administration:
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IP daily for 3 weeks.
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Result:
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Suppressed the lymph node metastatic capacities of PC-3M-Luc cells in the nude mice model.
Decreased the mRNA level of
CCL2
,
APLN
and
IL6ST
in implanted tumors.
Did not affect the body weight of the mice.
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SEC
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
1802997-81-4, SEC 相關(guān)搜索:
- 抑制劑
- 金黃色葡萄球菌腸毒素C(SEC)ELISA試劑盒
- 1802997-81-4
- SEC
- 1H-Pyrazole-5-carboxylic acid, 1-[(2S)-3-(4-chlorophenoxy)-2-hydroxypropyl]-3-(4-methoxyphenyl)-, ethyl ester