A 77-01
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- CAS號(hào):
- 607737-87-1
- 英文名:
- 4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE
- 英文別名:
- A77-01;A-77-01;A 77-01;CS-1775;A7701;A 7701; A-7701;A 77-01, 10 mM in DMSO;4-[3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoline;4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE;4-[5-(6-methylpyridin-2-yl)-1~{H}-pyrazol-4-yl]quinoline;Quinoline, 4-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-
- 中文名:
- A 77-01
- 中文別名:
- 化合物A77-01;化合物A77-01,10 MM DMSO 溶液;A 77-01 |CAS 607737-87-1;TGF-Β I型受體家族ALK5抑制劑(A 77-01);4-(3-(6-甲基吡啶-2-基)-1H-吡唑-4-基)喹啉;4-[3-(6-甲基-2-吡啶基)-1H-吡唑-4-基]喹啉
- CBNumber:
- CB6727914
- 分子式:
- C18H14N4
- 分子量:
- 286.33
- MOL File:
- 607737-87-1.mol
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A 77-01化學(xué)性質(zhì)
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儲(chǔ)存條件:
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Store at -20°C
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溶解度:
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insoluble in H2O; ≥14.3 mg/mL in DMSO; ≥8.84 mg/mL in EtOH with gentle warming and ultrasonic
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形態(tài):
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solid
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顏色:
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Off-white to light yellow
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A 77-01性質(zhì)、用途與生產(chǎn)工藝
A 77-01 是一種有效的 TGF-β I 型受體家族 ALK5 抑制劑，IC50 值為 25 nM。
A-77-01 (0.01-10 μM; 25 hours; Mv1Lu cells) treatment effectively inhibits TGF-β-induced transcriptional activation in concentration-dependent fashion.
A-77-01 (1 μM; 24-72 hours; Mv1Lu cells) treatment efficiently prevents the growth-inhibitory effects of TGF-β.
A-77-01 (1 μM; 30 minutes; HaCaT cells) treatment inhibits TGF-β-induced phosphorylation of Smad2.
RT-PCR
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Cell Line:
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Mv1Lu cells
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Concentration:
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0.01 μM, 0.03 μM, 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM
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Incubation Time:
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25 hours
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Result:
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Inhibited the luciferase activity induced by TGF-β in concentration-dependent fashion.
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Cell Viability Assay
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Cell Line:
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Mv1Lu cells
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Concentration:
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1 μM
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Incubation Time:
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24 hours, 48 hours, 72 hours
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Result:
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Efficiently prevented the growth-inhibitory effects of TGF-β.
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Western Blot Analysis
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Cell Line:
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HaCaT cells
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Concentration:
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1 μM
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Incubation Time:
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30 minutes
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Result:
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Inhibited TGF-β-induced phosphorylation of Smad2.
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A 77-01
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2025/02/08 | HY-78349 | A 77-01 | 607737-87-1 | 1 mg | 429元 |
| 2025/02/08 | HY-78349 | A 77-01
A 77-01 | 607737-87-1 | 5mg | 988元 |
607737-87-1, A 77-01 相關(guān)搜索:
- Inhibitors
- 酶
- 細(xì)胞生物學(xué)試劑
- 抑制劑
- 小分子抑制劑
- 小分子抑制劑，天然產(chǎn)物
- A 77-01 |CAS 607737-87-1
- 化合物A77-01,10 MM DMSO 溶液
- 4-(3-(6-甲基吡啶-2-基)-1H-吡唑-4-基)喹啉
- 化合物A77-01
- TGF-Β I型受體家族ALK5抑制劑(A 77-01)
- 4-[3-(6-甲基-2-吡啶基)-1H-吡唑-4-基]喹啉
- 607737-87-1
- A 77-01, 10 mM in DMSO
- TGF-β Receptor,Transforming growth factor beta receptors,A 77-01,Inhibitor,A 77 01,inhibit,A 7701
- Quinoline, 4-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-
- A7701;A 7701; A-7701
- 4-[5-(6-methylpyridin-2-yl)-1~{H}-pyrazol-4-yl]quinoline
- CS-1775
- 4-[3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoline
- 4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]quinoline A 77-01
- A77-01
- A-77-01
- A 77-01
- 4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE