432499-63-3
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- CAS號:
- 432499-63-3
- 英文名:
- 4E2RCat
- 英文別名:
- 4E2RCat;4E2RCat, 10 mM in DMSO;Eukaryotic Initiation Factor;5-(5-((3-Benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)-2-chlorobenzoic acid;4E-2RCat,Virus Protease,4E2RCat,Inhibitor,inhibit,Autophagy,Eukaryotic Initiation Factor (eIF);5-(5-((3-Benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)-2-chlorobenzoic acid[4E2RCat;Benzoic acid, 2-chloro-5-[5-[[4-oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-
- 中文名:
- 432499-63-3
- 中文別名:
- 化合物4E2RCAT;化合物 T14044;化合物4E2RCAT,10 MM DMSO 溶液;5-(5-((3-芐基-4-氧代-2-硫噻唑烷-5-亞基)甲基)呋喃-2-基)-2-氯苯甲酸
- CBNumber:
- CB63167593
- 分子式:
- C22H14ClNO4S2
- 分子量:
- 455.93
- MOL File:
- 432499-63-3.mol
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432499-63-3化學(xué)性質(zhì)
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沸點(diǎn):
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659.0±65.0 °C(Predicted)
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密度:
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1.56±0.1 g/cm3(Predicted)
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儲存條件:
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Store at -20°C
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溶解度:
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DMSO : 15.5 mg/mL (34.00 mM)
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形態(tài):
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Solid
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酸度系數(shù)(pKa):
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2.72±0.25(Predicted)
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顏色:
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Light yellow to yellow
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432499-63-3性質(zhì)、用途與生產(chǎn)工藝
4E2RCat是eIF4E-eIF4G相互作用的抑制劑，IC50值為13.5 μM。
IC50: 13.5 μM (eIF4E-eIF4G)
4E2RCat prevents the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), inhibiting cap-dependent translation. It significantly decreases human coronavirus 229E (HCoV-229E) replication, reducing the percentage of infected cells and intra- and extracellular infectious virus titers. 4E2RCat inhibits cap-dependent translation in a dose-dependent manner. 4E2RCat inhibits cap-dependent FF translation but not EMCV IRES-driven Ren translation. 4E2RCat inhibits coronavirus replication in a dose- and time-dependent manner.
4E2RCat inhibits protein synthesis
in vivo
and it is not a consequence of increased cell death.
432499-63-3
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
|---|
| 2025/02/08 | HY-100733 | 432499-63-3
4E2RCat | 432499-63-3 | 1mg | 720元 |
| 2025/02/08 | HY-100733 | 432499-63-3
4E2RCat | 432499-63-3 | 5mg | 1510元 |
432499-63-3, 432499-63-3 相關(guān)搜索:
- 抑制劑
- C22H14ClNO4S2
- 化合物4E2RCAT,10 MM DMSO 溶液
- 化合物4E2RCAT
- 化合物 T14044
- 5-(5-((3-芐基-4-氧代-2-硫噻唑烷-5-亞基)甲基)呋喃-2-基)-2-氯苯甲酸
- 432499-63-3
- 4E2RCat, 10 mM in DMSO
- 4E-2RCat,Virus Protease,4E2RCat,Inhibitor,inhibit,Autophagy,Eukaryotic Initiation Factor (eIF)
- 5-(5-((3-Benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)-2-chlorobenzoic acid[4E2RCat
- 5-(5-((3-Benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)-2-chlorobenzoic acid
- Eukaryotic Initiation Factor
- Benzoic acid, 2-chloro-5-[5-[[4-oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-
- 4E2RCat