N-(3-溴苯基)-3-[(六氫-1H-氮雜卓-1-基)磺酰基]-苯甲酰胺
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- CAS號:
- 420831-40-9
- 英文名:
- 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
- 英文別名:
- AK-7;CS-922;AK 7, >=98%;AK-7;AK7;AK 7;SIRT2 Inhibitor II;AK-7, 10 mM in DMSO;SIRT2 Inhibitor,AK-7;SIRT2 Inhibitor II, AK-7;SIRT2 INHIBITOR II;AK7;AK 7;3-(1-azepanylsulfonyl)-N-(3-bromophenyl)benzamide
- 中文名:
- N-(3-溴苯基)-3-[(六氫-1H-氮雜卓-1-基)磺?；鵠-苯甲酰胺
- 中文別名:
- 化合物AK-1;化合物 AK-7;AK-7,中樞活性SIRT2抑制劑;化合物AK-7,10 MM DMSO 溶液;3-(氮雜環(huán)庚烷-1-基磺?；?-N-(3-溴苯基)苯甲酰胺;N-(3-溴苯基)-3-[(六氫-1H-氮雜卓-1-基)磺?；鵠-苯甲酰胺
- CBNumber:
- CB52639218
- 分子式:
- C19H21BrN2O3S
- 分子量:
- 437.35
- MOL File:
- 420831-40-9.mol
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N-(3-溴苯基)-3-[(六氫-1H-氮雜卓-1-基)磺?；鵠-苯甲酰胺化學(xué)性質(zhì)
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密度:
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1.469±0.06 g/cm3(Predicted)
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儲存條件:
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Sealed in dry,2-8°C
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溶解度:
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DMSO: ≥15mg/mL
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形態(tài):
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powder
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酸度系數(shù)(pKa):
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12.28±0.70(Predicted)
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顏色:
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white to tan
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穩(wěn)定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
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N-(3-溴苯基)-3-[(六氫-1H-氮雜卓-1-基)磺酰基]-苯甲酰胺性質(zhì)、用途與生產(chǎn)工藝
AK-7 是一種可透過細(xì)胞及血腦屏障的 SIRT2 抑制劑，IC50 值為 15.5 μM。
AK-7 (10 μM) reduces cholesterol levels in naive N2a neuroblastoma cells and hippocampal slice cultures from wild-type mice. AK-7 (1 μM) shows neuroprotective effect of AK-7 in striatal Huntington’s disease (HD) neurons. AK-7 (12.5 μM) decreases ratio of DA neurons in primary midbrain cultures.
AK-7 (15 mg/kg/dose, i.p.) is brain-permeable in wild-type and HD mice. AK-7 (10, 20 mg/kg, i.p.) improves the behavior and neuropathological phenotype and extends survival of R6/2 HD mice. AK-7 (20 mg/kg) ameliorates HD neuropathology in R6/2 mice. AK-7 also reduces the polyglutamine aggregation in R6/2 brain. In addition, AK-7 treated 140CAG mice show motor performance changes that parallel untreated wild-type mice, with the 20 mg/kg dose being most effective and significantly different from untreated 140CAG mice.
N-(3-溴苯基)-3-[(六氫-1H-氮雜卓-1-基)磺?；鵠-苯甲酰胺
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價(jià)格 |
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| 2025/05/22 | HY-16691 | N-(3-溴苯基)-3-[(六氫-1H-氮雜卓-1-基)磺?；鵠-苯甲酰胺
AK-7 | 420831-40-9 | 1 mg | 306元 |
| 2025/05/22 | HY-16691 | N-(3-溴苯基)-3-[(六氫-1H-氮雜卓-1-基)磺?；鵠-苯甲酰胺
AK-7 | 420831-40-9 | 10mM * 1mLin DMSO | 661元 |
N-(3-溴苯基)-3-[(六氫-1H-氮雜卓-1-基)磺?；鵠-苯甲酰胺
生產(chǎn)廠家
420831-40-9, N-(3-溴苯基)-3-[(六氫-1H-氮雜卓-1-基)磺?；鵠-苯甲酰胺 相關(guān)搜索:
- 抑制劑
- 藥靶配體
- 化合物AK-7,10 MM DMSO 溶液
- 化合物 AK-7
- AK-7,中樞活性SIRT2抑制劑
- 3-(氮雜環(huán)庚烷-1-基磺?；?-N-(3-溴苯基)苯甲酰胺
- 化合物AK-1
- N-(3-溴苯基)-3-[(六氫-1H-氮雜卓-1-基)磺酰基]-苯甲酰胺
- 420831-40-9
- 3-(1-azepanylsulfonyl)-N-(3-bromophenyl)benzamide
- AK-7, 10 mM in DMSO
- SIRT2 Inhibitor II
- SIRT2 INHIBITOR II;AK7;AK 7
- CS-922
- SIRT2 Inhibitor II, AK-7
- AK-7;AK7;AK 7
- Benzamide, N-(3-bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-
- AK-7
- 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
- AK 7, >=98%
- N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide SIRT2 Inhibitor,AK-7
- SIRT2 Inhibitor,AK-7
- N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide