糠酸氟替卡松為源自氟替卡松的一種人工合成皮質類固醇，可治療過敏性鼻炎用。
糠酸氟替卡松(GW685698)是一種吸入性皮質類固醇/長效的β腎上腺素能受體激動劑的復方治療藥物，能延長支氣管擴張劑的作用時間。它被用于非過敏性和過敏性皮炎的治療。
Kd: 0.3 nM (Corticosteroid)
Fluticasone furoate comes in a nasal spray, as an aqueous suspension of micronized fluticasone furoate for topical administration to the nasal mucosa by means of a metering, atomizing spray pump. Fluticasone furonate displays great potency in inhibiting tumor necrosis factor synthesis and action. Fluticasone furonate is also potent in preventing damage to cultured human lung epithelial cells by different stimulus.
Fluticasone furonate is 99.4% bound to plasma protein in vitro and other research indicated extensive first-pass metabolism of the absorbed drug. Protein binding is highly relevant because only the unbound free drug can exert an effect at the receptor site. Clearance of Fluticasone furonate is primarily by hydrolysis in the liver by the cytochrome P450 isozyme (CYP) 3A4 that converts the drug to the 17β-carboxylic acid metabolite (M10), which displays low glucocorticoid receptor agonist potency. Fluticasone furonate is excreted mainly in the feces, with only minor amounts in the urine.