安三烯菌素B
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- CAS號:
- 82189-04-6
- 英文名:
- mycotrienin II
- 英文別名:
- mycotrienin II;T 23II, Mycotrienin II, T 23II;20,23-Didehydro-20,23-dideoxo-20,23-dihydroxyansatrienol A 11-[(R)-2-(cyclohexylcarbonylamino)propanoate];D-Alanine, N-(cyclohexylcarbonyl)-, (5R,6E,8E,10E,13S,14R,15R,16Z)-15,22,24-trihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(24),6,8,10,16,20,22-heptaen-13-yl ester
- 中文名:
- 安三烯菌素B
- 中文別名:
- 安薩特里恩B;安莎三烯 B;安三烯菌素B
- CBNumber:
- CB41375521
- 分子式:
- C36H50N2O8
- 分子量:
- 638.79
- MOL File:
- 82189-04-6.mol
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安三烯菌素B化學性質(zhì)
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儲存條件:
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-20°C
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溶解度:
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Soluble in DMSO, DMF, Ethanol or Methanol
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形態(tài):
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solid
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顏色:
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Pale-yellow
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穩(wěn)定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, ethanol, or methanol may be stored at -20°C for up to 3 months.
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安三烯菌素B性質(zhì)、用途與生產(chǎn)工藝
Ansatrienin B (Mycotrienin II) 是從鏈霉菌中分離得到的一種抗生素 (antibiotic)。Ansatrienin B 對真菌和酵母有活性，但對細菌無活性。Ansatrienin B 具有抗腫瘤活性，可作為 ADC 毒素分子。
Ansatrienin B exhibits antimicrobial activities of
Penicillium chrysogenuin
1AM 7106,
Mucor pusillus
IAM 6122,
Rhizopus delemar
IAM 6015,
Saccharornyces cerevisiae
IFO 0304,
Candida utilus
IFO 0396 and
Candida krusei
IFO 0590 with MIC values of 12.5 μg/ml, 12.5 μg/ml, 12.5 μg/ml, 8.0 μg/ml, 4.0 μg/ml, 4.0 μg/ml, and 4.0 μg/ml, respectively.
Ansatrienin B inhibits the release of
45
calcium into the culture medium by fetal rat long bones with an apparent halfmaximal inhibition (IC
50
) value of 21 nM.Ansatrienin B inhibits the translationof the protein synthesis stage by specific inhibition of L-leucine incorporation (IC
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=58 nM) in A549 cells). At the same time,?it also inhibits TNF-α-induced expression of ICAM-1 with an IC
50
of 300 nM.
Ansatrienin B (intraperitoneal injection; once daily; 6 days) is against P-388 -injected mouse tumor growth. The LD
50
value in mice of MTN-II is 80 mg/kg in CDF1 male mice.
安三烯菌素B
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
82189-04-6, 安三烯菌素B 相關搜索:
- 抑制劑
- 微生物代謝物
- 安薩特里恩B
- 安莎三烯 B
- 安三烯菌素B
- 82189-04-6
- D-Alanine, N-(cyclohexylcarbonyl)-, (5R,6E,8E,10E,13S,14R,15R,16Z)-15,22,24-trihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(24),6,8,10,16,20,22-heptaen-13-yl ester
- T 23II, Mycotrienin II, T 23II
- 20,23-Didehydro-20,23-dideoxo-20,23-dihydroxyansatrienol A 11-[(R)-2-(cyclohexylcarbonylamino)propanoate]
- mycotrienin II