CS-2493
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- CAS號(hào):
- 1357920-84-3
- 英文名:
- Belizatinib
- 英文別名:
- CS-2493;TSR-011;Belizatinib;Belizatinib (TSR011);Belizatinib, 10 mM in DMSO;TSR011; TSR011; TSR 011; BELIZATINIB;4-Fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-(cis-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2-yl)benzamide;Benzamide, 4-fluoro-N-[6-[[4-(1-hydroxy-1-methylethyl)-1-piperidinyl]methyl]-1-[cis-4-[[(1-methylethyl)amino]carbonyl]cyclohexyl]-1H-benzimidazol-2-yl]-;TSR011,Trk Receptor,CD246,ALK tyrosine kinase receptor,Tropomyosin related kinase receptor,TSR 011,inhibit,Cluster of differentiation 246,Belizatinib,Inhibitor,Anaplastic lymphoma kinase,Anaplastic lymphoma kinase (ALK)
- 中文名:
- CS-2493
- 中文別名:
- 貝扎替尼(TSR-011);化合物BELIZATINIB;化合物BELIZATINIB,10 MM DMSO 溶液;ALK和TRKA、TRKB、TRKC雙重抑制劑(BELIZATINIB);4-氟-N-(6-((4-(2-羥基丙烷-2-基)哌啶-1-基)甲基)-1-(順式-4-(異丙基氨甲酰)環(huán)己基)-1H-苯并[D]咪唑-2-基)苯甲酰胺
- CBNumber:
- CB13333605
- 分子式:
- C33H44FN5O3
- 分子量:
- 577.73
- MOL File:
- 1357920-84-3.mol
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CS-2493化學(xué)性質(zhì)
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密度:
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1.27±0.1 g/cm3(Predicted)
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儲(chǔ)存條件:
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Store at -20°C
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溶解度:
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DMF:30.0(Max Conc. mg/mL);51.93(Max Conc. mM)
DMSO:143.33(Max Conc. mg/mL);248.08(Max Conc. mM)
Ethanol:65.0(Max Conc. mg/mL);112.5(Max Conc. mM)-
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形態(tài):
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A crystalline solid
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酸度系數(shù)(pKa):
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12.55±0.43(Predicted)
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顏色:
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White to off-white
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CS-2493性質(zhì)、用途與生產(chǎn)工藝
Belizatinib (TSR-011)是一種有效的ALK（IC50=0.7 nM）和tropomyosin receptor kinase (TRK) （IC50<3 nM）抑制劑。
| Target | Value |
TrkA
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TrkB
()
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TrkC
()
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TrkA
()
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TrkB
()
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TSR-011對(duì)野生型重組ALK激酶活性具有高的親和力，IC50為0.7 nM；抑制原肌球蛋白受體激酶（TRK）A、B、C（IC50小于3 nM）。
在小鼠模型中，TSR-011能夠?qū)LK依賴的腫瘤生長(zhǎng)發(fā)揮有效的、持久的抑制作用。其耐受良好。
CS-2493
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2025/05/22 | HY-17603 | CS-2493
Belizatinib | 1357920-84-3 | 1 mg | 423元 |
| 2025/05/22 | HY-17603 | CS-2493
Belizatinib | 1357920-84-3 | 2mg | 600元 |
1357920-84-3, CS-2493 相關(guān)搜索:
- 抑制劑
- 合成有機(jī)化合物配體
- 細(xì)胞生物學(xué)試劑
- C33H44FN5O3
- 化合物BELIZATINIB,10 MM DMSO 溶液
- 貝扎替尼(TSR-011)
- 化合物BELIZATINIB
- 4-氟-N-(6-((4-(2-羥基丙烷-2-基)哌啶-1-基)甲基)-1-(順式-4-(異丙基氨甲酰)環(huán)己基)-1H-苯并[D]咪唑-2-基)苯甲酰胺
- ALK和TRKA、TRKB、TRKC雙重抑制劑(BELIZATINIB)
- 1357920-84-3
- Belizatinib, 10 mM in DMSO
- 4-Fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-(cis-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2-yl)benzamide
- TSR011,Trk Receptor,CD246,ALK tyrosine kinase receptor,Tropomyosin related kinase receptor,TSR 011,inhibit,Cluster of differentiation 246,Belizatinib,Inhibitor,Anaplastic lymphoma kinase,Anaplastic lymphoma kinase (ALK)
- Benzamide, 4-fluoro-N-[6-[[4-(1-hydroxy-1-methylethyl)-1-piperidinyl]methyl]-1-[cis-4-[[(1-methylethyl)amino]carbonyl]cyclohexyl]-1H-benzimidazol-2-yl]-
- TSR011; TSR011; TSR 011; BELIZATINIB
- CS-2493
- TSR-011
- Belizatinib (TSR011)
- Belizatinib