RP70676
|
|
|
- CAS號(hào):
- 136609-26-2
- 英文名:
- RP 70676
- 英文別名:
- RP 70676;RP 70676, 10 mM in DMSO;1H-Pyrazole, 1-[5-[(4,5-diphenyl-1H-imidazol-2-yl)thio]pentyl]-3,5-dimethyl-;RP 70676,RP-70676,Diacylglycerol acyltransferase,mono- acylglycerol acyltransferase,acyl-CoA:cholesterol acyltransferase,inhibit,RP70676,Inhibitor,Diglyceride acyltransferase,Acyltransferase
- 中文名:
- RP70676
- 中文別名:
- 化合物 T12767;RP 70676游離態(tài);化合物RP 70676;化合物RP 70676,10 MM DMSO 溶液
- CBNumber:
- CB13175577
- 分子式:
- C25H28N4S
- 分子量:
- 416.58
- MOL File:
- 136609-26-2.mol
|
|
|
RP70676化學(xué)性質(zhì)
-
沸點(diǎn):
-
605.9±57.0 °C(Predicted)
-
|
-
密度:
-
1.16±0.1 g/cm3(Predicted)
-
|
-
儲(chǔ)存條件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO (Slightly), Methanol (Slightly)
-
|
-
形態(tài):
-
Solid
-
|
-
酸度系數(shù)(pKa):
-
11.80±0.10(Predicted)
-
|
-
顏色:
-
White to Off-White
-
|
RP70676性質(zhì)、用途與生產(chǎn)工藝
RP 70676 是一種有效的 ACAT 抑制劑，能夠抑制對(duì)大鼠和兔子中的 ACAT 活性，IC50 值分別為 25 和 44 nM。
IC50: 25 nM (Rat ACAT), 44 nM (Rabbit ACAT)
RP 70676 is a potent inhibitor of rabbit arterial ACAT (IC
50
= 40 nM) and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC
50
values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues the mean IC
50
is 44 nM. In whole cell P388D, murine macrophages the compound has an IC
50
of 540 nM.
RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels in NZW rabbits.
RP70676
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2025/05/22 | HY-101576 | RP 70676 | 136609-26-2 | 1 mg | 803元 |
| 2025/05/22 | HY-101576 | RP 70676 | 136609-26-2 | 10 mM * 1 mLin DMSO | 1593元 |
136609-26-2, RP70676 相關(guān)搜索:
- 抑制劑
- 化合物RP 70676,10 MM DMSO 溶液
- 化合物RP 70676
- 化合物 T12767
- RP 70676游離態(tài)
- 136609-26-2
- RP 70676, 10 mM in DMSO
- RP 70676,RP-70676,Diacylglycerol acyltransferase,mono- acylglycerol acyltransferase,acyl-CoA:cholesterol acyltransferase,inhibit,RP70676,Inhibitor,Diglyceride acyltransferase,Acyltransferase
- 1H-Pyrazole, 1-[5-[(4,5-diphenyl-1H-imidazol-2-yl)thio]pentyl]-3,5-dimethyl-
- RP 70676