3-溴丙酮酸
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- CAS號:
- 1113-59-3
- 英文名:
- 3-Bromopyruvic acid
- 英文別名:
- 3-bromopyruvate;3-BROMOPYRUVIC ACID;3-BROMO-2-OXOPROPANOIC ACID;bromopyruvate;BROMOPYRUVIC ACID;2-Oxo-3-bromopropanoic acid;3-BROMO-2-OXOPROPIONIC ACID;beta-bromopyruvicacid;NSC 62343;NSC 11731
- 中文名:
- 3-溴丙酮酸
- 中文別名:
- 溴丙酮酸;3-溴庚酸;3-溴丙酮酸;3-溴代丙酮酸;溴丙酮酸,97%;3-溴丙酮酸97%;3-溴-2-氧代丙酸;3-溴-2-氧代丙酸3-溴丙酮酸;PERFEMIKER]溴丙酮酸,95%;3-溴丙酮酸、3-溴庚酸、3-溴代丙酮酸
- CBNumber:
- CB0380692
- 分子式:
- C3H3BrO3
- 分子量:
- 166.96
- MOL File:
- 1113-59-3.mol
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3-溴丙酮酸化學性質(zhì)
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熔點:
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77-82 °C
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沸點:
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223.4±23.0 °C(Predicted)
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密度:
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1.7314 (rough estimate)
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折射率:
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1.4650 (estimate)
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儲存條件:
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2-8°C
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溶解度:
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water: soluble1g/10 mL, clear, colorless
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形態(tài):
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White crystalline solid
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酸度系數(shù)(pKa):
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1.84±0.54(Predicted)
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顏色:
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White to Almost white
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水溶解性:
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Soluble in water, dimethyl sulfoxide, ethyl acetate and water.
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BRN:
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1746786
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InChIKey:
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PRRZDZJYSJLDBS-UHFFFAOYSA-N
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CAS 數(shù)據(jù)庫:
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1113-59-3(CAS DataBase Reference)
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EPA化學物質(zhì)信息:
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Propanoic acid, 3-bromo-2-oxo- (1113-59-3)
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3-溴丙酮酸性質(zhì)、用途與生產(chǎn)工藝
3-Bromopyruvic acid 是己糖激酶 II (hexokinase II, HXK II) 抑制劑，是一種有效的針對肝癌細胞的抗腫瘤劑。
3-Bromopyruvate enhances TRAIL-induced apoptosis in breast cancer cells.
3-Bromopyruvate (Bromopyruvic acid), a hexokinase II inhibitor, can induce apoptosis in hepatocellular carcinoma cells by inducing endoplasmic reticulum (ER) stress.
3-Bromopyruvate inhibits ATP generation and upregulates the expression of DR5. 3-Bromopyruvate upregulates CHOP, GRP78 and the phosphorylation of AMPK and augments TRAIL-induced Bax and caspase-3 levels.
Cell Viability Assay
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Cell Line:
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MCF-7 and MDA-MB-231 cells
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Concentration:
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40, 80, 160 or 320 μM
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Incubation Time:
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24 hours
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Result:
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3-Bromopyruvate (80 and 160 μmol/l) and TRAIL (400 ng/ml) significantly inhibited cell viability.
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3-Bromopyruvate (8 mg/kg; i.p.; every 4 days for 28 days) shows a synergistic antitumor effect in MCF-7 cell xenografts in nude mice.
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Animal Model:
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Female nude mice (BALB/c; 4-5-weeks old and 18-20 g)
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Dosage:
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8 mg/kg
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Administration:
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I.p.; every 4 days for 28 days
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Result:
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Showed antitumor efficacy in tumor xenografts.
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化學性質(zhì)
3-溴代丙酮酸是白色固體，m.p.64～67℃。不溶于水。
用途
3-溴代丙酮酸是殺菌劑噻菌靈的中間體。
用途
半胱氨酸殘基的親和標記;核酸和蛋白質(zhì)之間的交聯(lián)劑
生產(chǎn)方法
其制備方法是將丙酮酸中加入少許濃硫酸和溶劑二氯甲烷置于反應(yīng)瓶中，滴加溴約需3.5h，并攪拌，有白色沉淀產(chǎn)生，再繼續(xù)攪拌1h，用環(huán)己烷和石油醚稀釋，然后冷卻反應(yīng)混合物得到結(jié)晶，過濾，用石油醚洗滌并干燥得到產(chǎn)品。
類別
有毒物質(zhì)
毒性分級
高毒
急性毒性
腹腔-小鼠 LD50: 72 毫克/公斤
可燃性危險特性
熱分解排出有毒溴化物蒸汽
儲運特性
庫房通風低溫干燥; 與食品原料分開存放
滅火劑
泡沫、干粉、二氧化碳、霧狀水
3-溴丙酮酸
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
|---|
| 2025/05/22 | L00720 | 溴丙酮酸, 97%
Bromopyruvic acid, 97% | 1113-59-3 | 2g | 211元 |
| 2025/05/22 | L00720 | 溴丙酮酸, 97%
Bromopyruvic acid, 97% | 1113-59-3 | 10g | 878元 |
3-溴丙酮酸
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1113-59-3, 3-溴丙酮酸 相關(guān)搜索:
- Piperidines
- Carboxylic Acids
- Organic acids
- Carboxylic Acids
- Aliphatics
- 化學試劑
- 醫(yī)藥化工原料
- 抑制劑
- 高端化學
- 有機化學
- 有機化工
- 材料中間體及助劑
- 細胞生物學試劑
- 農(nóng)藥原料
- 苯并咪唑類殺菌劑
- 羰基化合物
- 有機酸
- 有機砌塊
- 羧酸
- 通用試劑
- 殺菌劑中間體
- 農(nóng)藥中間體
- Organic Building Blocks
- C1 to C5
- Carbonyl Compounds
- Carboxylic Acids
- Building Blocks
- C3H3BrO3
- BrCH2COCOOH
- C3H3O3Br
- HEXOKINASE II(己糖激酶II)抑制劑(3-BROMOPYRUVIC ACID)
- PERFEMIKER]溴丙酮酸,95%
- 優(yōu)選]3-BROMOPYRUVIC ACID
- 3-溴丙酮酸、3-溴庚酸、3-溴代丙酮酸
- 3-溴代丙酮酸
- 溴丙酮酸
- 3-溴丙酮酸97%
- 3-溴-2-氧代丙酸
- 3-溴庚酸
- 3-溴-2-氧代丙酸3-溴丙酮酸
- 3-溴丙酮酸
- 溴丙酮酸,97%
- 1113-59-3
- Bromopyruvic acid (3-BP)
- 3-Bromopyruvic Acid, ≥ 98.0%
- Bromopyruvic acid (3-bromopyruvic acid)
- beta-bromopyruvicacid
- 3-BROMO-2-OXOPROPIONIC ACID
- BROMOPYRUVIC ACID
- 3-BROMOPYRUVIC ACID
- 3-bromopyruvate
- bromopyruvate
- 2-Oxo-3-bromopropanoic acid
- 3-BROMO-2-OXOPROPANOIC ACID
- Bromopyruvic acid，98%
- 3-Bromopyruvic Acid >
- 3-Brom-2-oxopropionsure
- Hexokinase II Inhibitor II