3-Α-氨基膽甾烷(3AC)
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- CAS號:
- 2206-20-4
- 英文名:
- Cholestan-3-aMine, (3α,5α)-
- 英文別名:
- 3α-Aminocholestane;3α-Aminocholestane;3alpha-Aminocholestane;3Α-AMINOCHOLESTANE (3AC);(3α,5α)-Cholestan-3-amine;(3α,5α)-Cholestan-3-amine;3-a-aMinocholestane (3AC);Cholestan-3-aMine, (3α,5α)-;5alpha-Cholestan-3alpha-amine;3αAminocholestane,3α Aminocholestane
- 中文名:
- 3-Α-氨基膽甾烷(3AC)
- 中文別名:
- 3Α-氨基膽甾烷;3Α-氨基膽甾烷;化合物 T14037;3-Α-氨基膽甾烷(3AC);3偽-AMINOCHOLESTANE;5ALPHA-膽甾烷-3ALPHA-胺;SHIP1抑制劑(3Α-AMINOCHOLESTANE)
- CBNumber:
- CB02595032
- 分子式:
- C27H49N
- 分子量:
- 387.68
- MOL File:
- 2206-20-4.mol
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3-Α-氨基膽甾烷(3AC)化學(xué)性質(zhì)
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熔點:
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104.5-105.5℃ (methanol )
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沸點:
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160 °C(Press: 0.1 Torr)
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密度:
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0.930±0.06 g/cm3(Predicted)
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儲存條件:
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Store at -20°C
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溶解度:
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Chloroform: 30 mg/ml
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形態(tài):
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A solid
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酸度系數(shù)(pKa):
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10.94±0.70(Predicted)
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顏色:
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White to off-white
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3-Α-氨基膽甾烷(3AC)性質(zhì)、用途與生產(chǎn)工藝
3α-Aminocholestane 是含有選擇性 SH2 結(jié)構(gòu)域的肌醇-5'-磷酸酶 1 (SHIP1) 的抑制劑，其 IC50 值約為 2.5 μM。
OPM2 cell viability is effectively reduced by 3α-Aminocholestane (3AC) treatment. RPMI8226 and U266 cells show significantly less sensitivity to 3α-Aminocholestane treatment when compare with OPM2 cells, although viability is decreased significantly at concentrations of ≥12.5 μM. Treatment with 3α-Aminocholestane for 36 h severely reduces the percentage of cells in the S phase, which is accompanied by an increase of cells in the G2/M phase. In contrast, in the less proliferative RPMI8226 and U266 cells, cell cycle progression is blocked in the G0/G1 phase upon 3α-Aminocholestane treatment, in conjunction with a reduced percentage of cells undergoing the S phase.
It is found that 3α-Aminocholestane (3AC) results in reduced multiple myeloma (MM) growth
in vivo
, as determined by quantitation of free human Igλ light chain in the plasma after OPM2 challenge. In addition, reduced numbers of circulating OPM2 cells, as determined by human HLA-ABC staining, is observed in peripheral blood from 3α-Aminocholestane-treated mice compare with vehicle controls. Most importantly, 3α-Aminocholestane treatment results in significantly enhanced survival of mice after tumor challenge. In 3α-Aminocholestane-treated mice that resist treatment, it is found that MM tumors exhibit an upregulation of SHIP2, reminiscent of
in vitro
treatment of OPM2 cells and suggesting that SHIP1 inhibition may select for tumor cells with increased SHIP2 expression.
3-Α-氨基膽甾烷(3AC)
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2024/11/08 | HY-19776 | 3α-Aminocholestane | | 1 mg | 500元 |
| 2024/11/08 | HY-19776 | 3-Α-氨基膽甾烷(3AC)
3α-Aminocholestane | 2206-20-4 | 10mM * 1mLin Ethanol | 938元 |
3-Α-氨基膽甾烷(3AC)
生產(chǎn)廠家
2206-20-4, 3-Α-氨基膽甾烷(3AC) 相關(guān)搜索:
- 抑制劑
- 制劑-抑制劑
- 細胞生物學(xué)試劑
- C27H49N
- 3Α-氨基膽甾烷
- 化合物 T14037
- SHIP1抑制劑(3Α-AMINOCHOLESTANE)
- 3偽-AMINOCHOLESTANE
- 3Α-氨基膽甾烷
- 5ALPHA-膽甾烷-3ALPHA-胺
- 3-Α-氨基膽甾烷(3AC)
- 2206-20-4
- (1R,3aS,3bR,5aS,7R,9aS,9bS,11aR)-9a,11a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-hexadecahydro-1H-cyclopenta[a]phenanthren-7-amine
- 3αAminocholestane,3α Aminocholestane
- 3α-Aminocholestane
- 3Α-AMINOCHOLESTANE (3AC)
- (3α,5α)-Cholestan-3-amine
- (3α,5α)-Cholestan-3-amine
- 3α-Aminocholestane
- 3-a-aMinocholestane (3AC)
- Cholestan-3-aMine, (3α,5α)-
- 5alpha-Cholestan-3alpha-amine
- 3alpha-Aminocholestane