997-68-2
997-68-2 結(jié)構(gòu)式
基本信息
中文別名
L-酵母氨酸 英文別名
saccharopineL-SACCHAROPINE
ω-N-(L-glutar-2-yl)-L-lysine
epsilon-N-(L-Glutar-2-yl)-L-lysine
N6-(L-1,3-dicarboxylpropyl)-L-lysine
N-(5-Amino-5-carboxypentyl)-L-glutamic acid
N-[(S)-5-Amino-5-carboxypentyl]-L-glutamic acid
N-[(5S)-5-Amino-5-carboxypentyl]-L-glutamic acid
L-Glutamic acid, N-[(5S)-5-amino-5-carboxypentyl]-
2-[(5-amino-5-carboxy-pentyl)amino]pentanedioic acid
物理化學(xué)性質(zhì)
熔點(diǎn)257-259℃ (Decomposition)
比旋光度D23 +33.6° (c = 1 in 0.5N HCl)
沸點(diǎn)537.2±50.0 °C(Predicted)
密度1.333±0.06 g/cm3(Predicted)
儲(chǔ)存條件−20°C
酸度系數(shù)(pKa)pK2 2.6; pK3 4.1; pK4 9.2; pK5 10.3(at 25℃)
常見問(wèn)題列表
生物活性
Saccharopine (L-Saccharopine) 是賴氨酸的降解中間體，是一種線粒體毒素。賴氨酸-酮戊二酸還原酶將賴氨酸和 α-酮戊二酸轉(zhuǎn)化為 Saccharopine。糖精脫氫酶將 Saccharopine 氧化為 α-氨基己酸酯半醛和谷氨酸。Saccharopine 通過(guò)破壞線粒體穩(wěn)態(tài)而損害發(fā)育。體外研究
Saccharopine accumulation leads to mitochondrial damage and functional loss which is induced by saccharopine dehydrogenase (SDH) mutations of α-aminoadipate semialdehyde synthase (AASS)-1 in C. elegans .
體內(nèi)研究
Saccharopine accumulation induces mitochondrial damage and progressive postnatal growth retardation in Aass mutant mice.