97534-21-9
97534-21-9 結(jié)構(gòu)式
基本信息
MERBARONE CALBIOCHEM
RLBN-1001
MERBARONE
NSC-336628
Merbarone - CAS 97534-21-9 - Calbiochem
5-(N-PHENYLCARBAMOYL)-2-THIOBARBITURIC ACID
5-(N-PHENYLCARBOXAMIDO)-2-THIOBARBITURIC ACID
5-(N-Phenylcarbamoyl)-2-thiobarbituric acid, NSC-336628
hexahydro-4,6-dioxo-n-phenyl-2-thioxo-5-pyrimidinecarboxamid
4,6-dioxo-N-phenyl-2-sulfanylidene-1,3-diazinane-5-carboxamide
物理化學(xué)性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/02/05 | HY-19024 | 化合物 T28017 Merbarone | 97534-21-9 | 5mg | 550元 |
| 2025/02/05 | HY-19024 | 化合物 T28017 Merbarone | 97534-21-9 | 10 mg | 850元 |
| 2025/02/05 | HY-19024 | 化合物 T28017 Merbarone | 97534-21-9 | 10 mM * 1 mLin DMSO | 880元 |
常見問題列表
topoisomerase II
Merbarone (1-100 μM) inhibits L1210 cells proliferation in a concentration-dependent manner, with an IC
50
of 10 μM.
Merbarone (10-200 μM; 10 min) inhibits DNA relaxation catalyzed by human topoisomerase IIα, with an IC
50
of ～40 μM.
Merbarone (25-200 μM; 6 min) blocks tyopoisomerase II-mediated DNA cleavage, with an IC
50
of ～50 μM.
Merbarone (100 μM; 6 min) inhibits topoisomerase II-mediated DNA cleavage in a global manner.
Merbarone (100 μM; 6 min) does not impair topoisomerase II?DNA binding.
Merbarone (200 μM; 4-16 min) does not inhibit topoisomerase II-catalyzed ATP hydrolysis.
Merbarone (50 mg/kg; daily i.p. for 5 d) achieves a maximum increased life span (ILS) of 101% in P388 murine leukemia.
Merbarone (124 mg/kg; daily p.o. for 9 d) has anti-tumor activity in mice.