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94356-26-0

中文名稱 曲札芪苷
英文名稱 Piceatannol 3'-O-glucoside
CAS 94356-26-0
分子式 C20H22O9
分子量 406.38
MOL 文件 94356-26-0.mol
更新日期 2025/02/06 13:41:51
94356-26-0 結(jié)構(gòu)式 94356-26-0 結(jié)構(gòu)式

基本信息

中文別名
曲札芪苷
曲札茋苷
白皮杉醇-3'-O-葡萄糖苷
反式-白皮杉醇-3-O-葡萄糖苷
白皮杉醇-3'-O-葡萄糖苷對(duì)照品
白皮杉醇-3'-O-葡萄糖苷標(biāo)準(zhǔn)品
曲札茋苷、白皮杉醇-3'-O-葡萄糖苷
英文別名
Quzhaqigan
Piceatannol 3'
Piceatannol 3-glycoside
Piceatannol 3'-O-glucoside
trans-Piceatannol 3-glucoside
Piceatannol 3'-O-beta-D-glucopyranoside
3,5,3',4'-trihydroxy-stilbene -3'-b-D-glucoside
β-D-Glucopyranoside, 5-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]-2-hydroxyphenyl
(E)-1-(3,5-dihydroxyphenyl)-2-(3-hydroxy-4-O-β-D-glucopyranose phenyl)ethylene
所屬類別
天然產(chǎn)物:酚類

物理化學(xué)性質(zhì)

熔點(diǎn)>219°C (dec.)
沸點(diǎn)721.6±60.0 °C(Predicted)
密度1.593±0.06 g/cm3(Predicted)
儲(chǔ)存條件Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度DMSO(輕微)、乙醇(輕微、超聲處理)、甲醇(輕微)
酸度系數(shù)(pKa)9.16±0.10(Predicted)
形態(tài)固體
顏色白色至灰白色
曲札芪苷價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2025/02/05HY-N2237曲札芪苷
Piceatannol 3'-O-glucoside
94356-26-01mg700元
2025/02/05HY-N2237曲札芪苷
Piceatannol 3'-O-glucoside
94356-26-05 mg1650元
2025/02/05HY-N2237曲札芪苷
Piceatannol 3'-O-glucoside
94356-26-010 mg2500元

常見問題列表

生物活性
Piceatannol 3'-O-glucoside 是 Rhubarb 的一種活性成分,通過抑制精氨酸酶 (Arginase) 活性激活內(nèi)皮細(xì)胞一氧化氮合酶 (NO synthase),抑制 Arginase I 和 Arginase II,IC50 值分別為 11.22 μM 和 11.06 μM。
靶點(diǎn)

NO synthase
IC50: 11.22 μM (Arginase I), 11.06 μM (Arginase II)

體外研究

Piceatannol 3'-O-glucoside (Piceatannol-3'-O-β-D-glucopyranoside; PG) is a potent component of stilbenes, inhibits the activity of arginase I and II prepared from mouse liver and kidney lysates, respectively, in a dose-dependent manner. In human umbilical vein endothelial cells, incubation of Piceatannol 3'-O-glucoside markedly blocks arginase activity and increases nitrite and nitrate (NOx) production, as measured by Griess assay. In liver lysates, incubation of different concentrations of Piceatannol 3'-O-glucoside significantly decreases arginase I activity (75±5% at 1 μM, 72±7% at 3 μM, 62±1% at 10 μM) compared to untreated control (100±9%). In kidney lysates, the residual arginase activities after incubation of 1, 3 and 10 μM Piceatannol 3'-O-glucoside are 75±6, 74±5, and 53±8%, respectively. Arginase activity is measured in the presence of different concentration of Piceatannol 3'-O-glucoside (from 0 to 120 μM) using liver lysate and kidney lysate. The 50% inhibitory concentrations (IC 50 ) are 11.22 μM for the liver lysate and 11.06 μM for kidney lysate. The values are obtained using the software of Graphpad prizm 4.0. Piceatannol 3'-O-glucoside inhibits arginase activity and increases NO production in HUVECs. Piceatannol 3'-O-glucoside inhibits lipoxygenase activity upto 66% at the concentration of 100 μM and IC 50 value is 69 μM.

體內(nèi)研究

In order to ascertain whether Piceatannol 3'-O-glucoside (PG) ameliorates vascular function in wild-type (WT) and atherogenic model mice [apolipoprotein E-null mice (ApoE -/- )] and to investigate the possible underlying mechanism. Preincubation of aortic vessels from WT mice fed a normal diet (ND) with Piceatannol 3'-O-glucoside attenuates vasoconstriction response to U46619 and phenylephrine (PE), while the vasorelaxant response to acetylcholine (Ach) is markedly enhanced in an endothelium-dependent manner. Piceatannol 3'-O-glucoside treatment attenuates the phenylephrine (PE)-dependent contractile response, and significantly improves the acetylcholine (Ach)-dependent vasorelaxation response in aortic rings from ApoE -/- mice fed a high-cholesterol diet (HCD). Piceatannol 3'-O-glucoside administration in the drinking water significantly reduces fatty streak formation in ApoE -/- mice fed an HCD.

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