92586-35-1
中文名稱
AZT TRIPHOSPHATE
英文名稱
3'-Azido-3'-deoxythymidine-5'-triphosphate
CAS
92586-35-1
分子式
C10H16N5O13P3·xLi
MOL 文件
92586-35-1.mol
92586-35-1 結構式
基本信息
英文別名
Zidovudinetriphosphatezidovudine 5'-triphosphate
3'-Azido-3'-deoxythymidine-5'-triphosphate lithium salt - 100mM aqueous solution
常見問題列表
生物活性
AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) 是一種 Zidovudine (AZT) 的活性三磷酸酯代謝產物。AZT triphosphate 具有抗逆轉錄病毒的活性，并抑制 HIV 復制。AZT triphosphate 還可抑制 HBV 的 DNA 聚合酶。AZT triphosphate 可激活線粒體介導的凋亡 (apoptosis) 途徑。靶點
HIV
HBV
DNA polymerase
Reactive oxygen species (ROS)
體外研究
Treatment with 100 μM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in H9c2 cells. AZT triphosphate accumulation causes downregulation of Opa1 and upregulation of Drp1. AZT triphosphate causes mitochondrial dysfunction, increases the production of cytotoxic reactive oxygen species (ROS), and impairs the balance of the mitochondrial quality control system in H9c2 cell model established from rat embryonic myoblasts.