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877399-53-6

中文名稱 化合物 T1661L
英文名稱 Crizotinib acetate
CAS 877399-53-6
分子式 C23H26Cl2FN5O3
分子量 510.39
MOL 文件 877399-53-6.mol
877399-53-6 結(jié)構(gòu)式 877399-53-6 結(jié)構(gòu)式

基本信息

中文別名
化合物 T1661L
英文別名
Crizotinib acetate

應(yīng)用領(lǐng)域

用途一
Crizotinib, also known as PF-02341066, is an orally bioavailable agent belonging to the class of c-met/hepatocyte growth factor receptor (HGFR) tyrosine kinase inhibitors with potential antineoplastic activity. Crizotinib was approved for treatment of some non-small cell lung carcinoma (NSCLC) in the US, and undergoing clinical trials testing its safety and efficacy in anaplastic large cell lymphoma, neuroblastoma, and other advanced solid tumors in both adults and childre. Crizotinib inhibits the membrane receptor MET and activation of the MET signaling pathway, which may block tumor cell growth, migration and invasion, and tumor angiogenesis in susceptible tumor cell populations. Crizotinib was approved in 2011.
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