861139-16-4
中文名稱(chēng)
861139-16-4
英文名稱(chēng)
N-(2-hydroxyethyl)-4-methoxy-N-methyl-3-(6-methyl[1,2,4]triazolo[3,4-a]phthalazin-3-yl)benzenesulfonamide
CAS
861139-16-4
分子式
C20H21N5O4S
分子量
427.48
MOL 文件
861139-16-4.mol
更新日期
2025/01/22 13:26:31
861139-16-4 結(jié)構(gòu)式
基本信息
中文別名
化合物RSV-IN-1 英文別名
RSV-IN-1N-(2-hydroxyethyl)-4-methoxy-N-methyl-3-(6-methyl[1,2,4]triazolo[3,4-a]phthalazin-3-yl)benzenesulfonamide
Benzenesulfonamide, N-(2-hydroxyethyl)-4-methoxy-N-methyl-3-(6-methyl-1,2,4-triazolo[3,4-a]phthalazin-3-yl)-
物理化學(xué)性質(zhì)
密度1.43±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : 125 mg/mL (292.41 mM);Water : < 0.1 mg/mL (insoluble)
酸度系數(shù)(pKa)14.21±0.10(Predicted)
形態(tài)Solid
常見(jiàn)問(wèn)題列表
生物活性
RSV-IN-1 是人呼吸道合胞病毒 (hRSV) 的抑制劑，其 IC50 值為 0.11 μM。靶點(diǎn)
IC50: 0.11μM (hRSV).
體外研究
The concentration of P13 that reduces the number of RSV plaques in HEp-2 cells by 50% (IC 50 ) is 0.11 μM. The concentration of P13 that reduces the viability of HEp-2 by 50% (CC 50 ) is 310 μM. Note that some cytotoxicity of P13 observed at 500 μM might be due to DMSO solvent. Hence, the selective index (CC 50 /IC 50 ) values is 2818 for P13. Note that even at the relatively high concentrations P13 does not completely block the development of RSV plaques. These escape plaques are of smaller size and of non-syncytial phenotype as compared to plaques formed in the absence of inhibitor.