80288-49-9
中文名稱
呋喃茶堿
英文名稱
3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE
CAS
80288-49-9
分子式
C12H12N4O3
分子量
260.25
MOL 文件
80288-49-9.mol
更新日期
2024/09/02 17:18:51
80288-49-9 結(jié)構(gòu)式
基本信息
中文別名
呋拉茶堿呋喃菲林
呋喃茶堿
英文別名
FURAFYLLINEFURAFYLLINE INHIBITOR OF CYTOCHRO
3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE
1H-Purine-2,6-dione, 3-(2-furanylmethyl)-3,9-dihydro-1,8-dimethyl-
Furafylline,3-(2-Furanylmethyl)-3,7-dihydro-1,8-dimethyl-1H-purine-2,6-dione
所屬類別
有機原料：雜環(huán)化合物物理化學性質(zhì)
熔點>162°C (dec.)
沸點543.6±60.0 °C(Predicted)
密度1.443±0.06 g/cm3(Predicted)
儲存條件Keep in dark place,Sealed in dry,2-8°C
溶解度ethanol: 0.33 mg/mL
酸度系數(shù)(pKa)8.62±0.70(Predicted)
形態(tài)solid
顏色white
InChIKeyKGQZGCIVHYLPBH-UHFFFAOYSA-N
常見問題列表
生物活性
Furafylline 是一種有效且有選擇性的人細胞色素 P450IA2 抑制劑，其 IC50 值為 0.07 μM。靶點
IC50: 0.07 μM (human cytochrome P450IA2)
體內(nèi)研究
Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC 50 of 0.07 μM in kinase experiment. Furafylline is a methylxanthine derivative that is introduced as a long-acting replacement for theophylline in the treatment of asthma. Administration of Furafylline is associated with an elevation in plasma levels of caffeine, due to inhibition of caffeine oxidation, a reaction catalysed by one or more hydrocarbon-inducible isoenzymes of P450. Furafylline has either very little or no effect on human monooxygenase activities catalysed by other isoenzymes of P450, including P4501ID1, P4501IC, P450IIIA.