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783292-37-5

中文名稱 阿巴卡韋雜質(zhì)
英文名稱 Abacavir
CAS 783292-37-5
分子式 C14H18N6O
分子量 286.33
MOL 文件 783292-37-5.mol
783292-37-5 結(jié)構(gòu)式 783292-37-5 結(jié)構(gòu)式

基本信息

中文別名
阿巴卡韋雜質(zhì)4
阿巴卡韋雜質(zhì)D
阿巴卡韋EP雜質(zhì)D
英文別名
(Abacavir EP Impurity D)
Abacavir Impurity 4(Abacavir EP Impurity D)
[(1R,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-enyl]methanol
(1R,?4R)?-?rel-4-?[2-Amino-?6-?(cyclopropylamino)?-?9H-?purin-?9-?yl]?-?2-?cyclopentene-?1-?methanol

應(yīng)用領(lǐng)域

用途一
(1R,?4R)?-?rel-4-?[2-Amino-?6-?(cyclopropylamino)?-?9H-?purin-?9-?yl]?-?2-?cyclopentene-?1-?methanol (Abacavir EP Impurity D) is an impurity of Abacavir A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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