78310-77-7
中文名稱
胸腺因子X
英文名稱
Thymus factor x
CAS
78310-77-7
常見問題列表
用途
胸腺因子X是一種蛋白質(zhì)，在動物模型中已被證明可以抑制癌細(xì)胞的增殖。它也被證明對腸系膜癌細(xì)胞和人類乙型肝炎病毒的生長有抑制作用。它可通過與單克隆抗體結(jié)合并觸發(fā)導(dǎo)致DNA分解的細(xì)胞事件來刺激細(xì)胞凋亡或程序性細(xì)胞死亡。它還抑制響應(yīng)皮膚測試的炎性細(xì)胞因子的產(chǎn)生。胸腺因子X對結(jié)核病、細(xì)菌性肺炎和水痘等傳染病具有活性。目前正在研究該藥物用于治療原發(fā)性硬化性膽管炎，這是一種膽管慢性炎癥性疾病。它還可用于治療自身免疫性疾病，如類風(fēng)濕性關(guān)節(jié)炎和多發(fā)性硬化癥，但在批準(zhǔn)用于任何治療目的之前需要進(jìn)行進(jìn)一步的研究。應(yīng)用
胸腺因子X是一種生物活性多肽，可用作淋巴細(xì)胞功能的天然刺激物。
生物活性
Thymic factor X (TFX-Jelfa) 是一種來自幼年小牛胸腺的水提取物，也是一種天然的淋巴細(xì)胞功能刺激劑。體內(nèi)研究
The percentage of necrotic lymphocytes in the spleen in Group I (infected with T. spiralis and treated with Thymus factor X (TFX)) is significantly lower than in the control group on day 7, and approximately the same as in the control group for the rest of the experiment. The percentage of necrotic lymphocytes in muscle tissue in Group I is approximately the same as in the control group on day 7, significantly lower on days 14 and 21 (p<0.0002), approximately the same on days 28 and 35, significantly lower on day 42, and significantly higher on day 60 (p<0.005).