7699-35-6
中文名稱
(E)-3-(3H-咪唑-4-基)丙-2-烯酸
英文名稱
(E)-3-(3H-imidazol-4-yl)prop-2-enoic acid
CAS
7699-35-6
分子式
C6H6N2O2
分子量
138.12
MOL 文件
7699-35-6.mol
更新日期
2023/03/20 15:41:21
7699-35-6 結(jié)構(gòu)式
基本信息
中文別名
順式-尿刊酸順-咪唑丙烯酸
順 - 尿刊酸
(E)-3-(3H-咪唑-4-基)丙-2-烯酸
英文別名
cis-UCANsc407934
(Z)-Urocanic acid
cis-Urocanic acid
Urocanic acid, cis
Cis-Urocanic Acid-[13C3]
(αZ)-1H-Imidazole-4-acrylic acid
(Z)-3-(1H-Imidazole-4-yl)acrylic acid
(Z)-3-(1H-Imidazol-4-yl)propenoic acid
(2Z)-3-(1H-Imidazole-4-yl)acrylic acid
物理化學(xué)性質(zhì)
熔點(diǎn)175-176 °C
沸點(diǎn)456.9±20.0 °C(Predicted)
密度1.430±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C
溶解度H2O：>10mg/mL
酸度系數(shù)(pKa)2.82±0.28(Predicted)
形態(tài)固體（蓬松的）
顏色白色
水溶解性溶于水
敏感性感光
(E)-3-(3H-咪唑-4-基)丙-2-烯酸價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/02/08 | HY-113008A | (E)-3-(3H-咪唑-4-基)丙-2-烯酸 cis-Urocanic acid | 7699-35-6 | 1 mg | 2133元 |
| 2025/02/08 | HY-113008A | (E)-3-(3H-咪唑-4-基)丙-2-烯酸 cis-Urocanic acid | 7699-35-6 | 5mg | 4200元 |
| 2025/02/08 | HY-113008A | (E)-3-(3H-咪唑-4-基)丙-2-烯酸 cis-Urocanic acid | 7699-35-6 | 10mM * 1mLin Water | 4620元 |
常見問題列表
生物活性
cis-Urocanic acid 是一種 5-HT2A 受體激動(dòng)劑。cis-Urocanic acid 以較高親和力與 5-HT 受體結(jié)合，Kd 為 4.6 nM。cis-Urocanic acid 是一種免疫調(diào)節(jié)劑，通過與 5-HT2A 受體結(jié)合而誘導(dǎo)免疫抑制。靶點(diǎn)
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5-HT 2A Receptor
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體外研究
Treatment with 100 μg/mL cis-Urocanic acid (cis-UCA) completely suppresses IL-6 and IL-8 secretion, decreases caspase-3 activity, and improves cell viability against UV-B irradiation. No significant effects on IL-6 or IL-8 secretion, caspase-3 activity, or viability of the non-irradiated cells are observed with 100 μg/mL cis-Urocanic acid in both cell types. The 5000 μg/mL concentration is toxic.
Cell Viability Assay
| Cell Line: | Human corneal epithelial cells (HCE-2) and human conjunctival epithelial cells (HCECs) |
| Concentration: | 10, 100, 1,000, and 5,000 μg/mL |
| Incubation Time: | 24, 48, or 72 hours |
| Result: | Treatment with 100 μg/mL completely suppressed IL-6 and IL-8 secretion, decreased caspase-3 activity, and improved cell viability against UV-B irradiation. No significant effects on IL-6 or IL-8 secretion, caspase-3 activity, or viability of the non-irradiated cells were observed with 100 μg/mL in both cell types. |