76150-91-9
中文名稱
TCPOBOP
英文名稱
TCPOBOP
CAS
76150-91-9
分子式
C16H8Cl4N2O2
分子量
402.06
MOL 文件
76150-91-9.mol
更新日期
2025/01/02 09:10:51
76150-91-9 結(jié)構(gòu)式
基本信息
中文別名
化合物TCPOBOP1,4-雙((3,5-二氯吡啶-2-基)氧基)苯
英文別名
TCPOBOP3,3',5,5'-TETRACHLORIDE-BPB
TCPOBOP - CAS 76150-91-9 - Calbiochem
1,4-Bis(3,5-dichloro-2-pyridyloxy)benzene
1,4-BIS[2-(3,5-DICHLOROPYRIDYLOXY)]BENZENE
1,4-Bis(3,5-Dichloro-2-pyridinyloxy)benzene
3,3',5,5'-TETRACHLORIDE-BISPYRIDYLOXYBENZENE
1,4-Bis[(3,5-dichloropyridin-2-yl)oxy]benzene
3,3′,5,5′-Tetrachloro-1,4-bis(pyridyloxy)benzene
2,2'-(p-Phenylenebisoxy)bis(3,5-dichloropyridine)
物理化學(xué)性質(zhì)
沸點(diǎn)444.8±45.0 °C(Predicted)
密度1.518±0.06 g/cm3(Predicted)
儲存條件2-8°C
溶解度DMSO: >10 mg/mL
酸度系數(shù)(pKa)-0.52±0.10(Predicted)
形態(tài)solid
顏色white
穩(wěn)定性Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
常見問題列表
生物活性
TCPOBOP 是一種組成型雄甾烷受體 (CAR) 激動劑，可誘導(dǎo)強(qiáng)健的肝細(xì)胞增殖和肝腫大，無任何肝損傷或組織缺失。TCPOBOP 通過改變 Bcl-2 蛋白減弱 Fas 誘導(dǎo)的小鼠肝損傷。靶點(diǎn)
|
Bcl-2
|
體內(nèi)研究
TCPOBOP (oral; 3 mg/kg; 1-5 days) remarkable increases Liver weight to body weight in LW/BW ratio at 48 hours.
| Animal Model: | MET fl/fl : Tam-Cre +/+ mice with a targeted deletion for exon 16 with MET KO |
| Dosage: | 3 mg/kg |
| Administration: | Oral; 1, 2, 5 days |
| Result: | Increased Liver weight to body weight. |