7182-54-9
7182-54-9 結(jié)構(gòu)式
基本信息
中文別名
單活菌素 英文別名
monactin5-deMethyl-5-ethylnonactin, AKD 1B
4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone, 5-ethyl-2,11,14,20,23,29,32-heptamethyl-, (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-
常見問題列表
生物活性
Monactin 是一種抗生素，也是單價陽離子 (包括鉀、鈉和鋰) 的非選擇性離子載體。Monactin 是從鏈霉菌中分離出來，并具有抗增殖活性。體外研究
Monactin displays strong antiproliferative activity against A2780 ovarian cancer cells (IC
50
0.13 μM), A2058 melanoma cells (0.02 μM), and H522-T1 non small-cell cancer lung cells (0.01 μM).
Monactin inhibits TCF/β-catenin transcriptional activity.
At a concentration of 10 μM, nigericin and monactin inhibited growth of Streptococcus faecalis, and the inhibition was reversed by addition of excess K(+).
體內(nèi)研究
Monactin is potent uncoupler of oxidative phosphorylation and inducer of ATP hydrolysis in rat liver mitochondria.