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6729-55-1

中文名稱 Γ-D-谷氨?;拾彼?
英文名稱 H-D-GLU(GLY-OH)-OH
CAS 6729-55-1
分子式 C7H12N2O5
分子量 204.18
MOL 文件 6729-55-1.mol
更新日期 2025/02/07 16:04:11
6729-55-1 結構式 6729-55-1 結構式

基本信息

中文別名
Γ-D-谷氨?;拾彼?BR>Γ-D-GLUTAMYLGLYCINE
英文別名
gDGG
GAMMA DGG
DGG gamma-
-DGG
GAMMA-D-GLU-GLY
D-gamma-Glu-Gly
H-D-GLU(GLY-OH)-OH
γ-D-Glutamylglycine
g-D-Glutamylglycine
H-GAMMA-D-GLU-GLY-OH
所屬類別
生物化工:甘氨酸類衍生物

物理化學性質(zhì)

熔點~191℃
沸點586.6±50.0 °C(Predicted)
密度1.424±0.06 g/cm3(Predicted)
儲存條件-15°C
溶解度Water:85.21(Max Conc. mg/mL);417.32(Max Conc. mM)
酸度系數(shù)(pKa)2.21±0.10(Predicted)
形態(tài)粉末
顏色White to off-white
Γ-D-谷氨?;拾彼醿r格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2025/02/08HY-100785Γ-D-谷氨酰基甘氨酸
gamma-DGG
6729-55-15mg500元
2025/02/08HY-100785Γ-D-谷氨?;拾彼?BR>gamma-DGG6729-55-110mM * 1mLin Water550元
2025/02/08HY-100785Γ-D-谷氨?;拾彼?BR>gamma-DGG6729-55-110mg700元

常見問題列表

生物活性
gamma-DGG 是一種競爭性的 AMPA 受體阻斷劑。
靶點

AMPA receptor

體外研究

gamma-DGG (γ-DGG), a competitive AMPA receptor blocker that blocks less at higher glutamate concentration. At 200-400 μM, gamma-DGG in the bath reduces the miniature EPSC (mEPSC) amplitude by 26±2% (n=5 synapses), and shifts both the mEPSC amplitude distribution and the cumulative probability curve to the left. gamma-DGG (γ-DGG) is the most effective antagonist of the excitatory post-synaptic potentials (e.p.s.p.s). Its action is reversible and not associated with any change in the passive membrane properties of the granule cells or in the apparent reversal potential of the e.p.s.p. Quantal analysis shows that the reduction in the e.p.s.p. paralleled the decrease in quantal size rather than quantal content, confirming a post-synaptic site of the action of gamma-DGG.

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