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6019-39-2

中文名稱 OAC2
英文名稱 5-benzoylaminoindole
CAS 6019-39-2
分子式 C15H12N2O
分子量 236.27
MOL 文件 6019-39-2.mol
更新日期 2025/01/10 15:39:02
6019-39-2 結構式 6019-39-2 結構式

基本信息

中文別名
N-(1H-吲哚-5-基)苯甲酰胺
N-(1H-吲哚-5-基)苯甲酰胺, >98%
英文別名
OAC2
CS-2128
OAC2?, >98%
OAC-2
OAC 2
5-benzoylaminoindole
N-(1H-Indol-5-yl)benzaMide
Benzamide, N-1H-indol-5-yl-

物理化學性質

熔點165 - 167°C
沸點364.3±15.0 °C(Predicted)
密度1.307±0.06 g/cm3(Predicted)
儲存條件Sealed in dry,Room Temperature
溶解度可溶于DMSO(少許)、甲醇(少許)
酸度系數(shù)(pKa)13.99±0.43(Predicted)
形態(tài)固體
顏色淡黃色

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302-H317
防范說明P280

圖譜信息

常見問題列表

生物活性
OAC-2是transcription factor 4 (OCT4)的激活劑,增強iPSC重編程效率。
靶點
TargetValue
OCT4
()
體外研究

Octamer-binding transcription factor 4 (Oct4) is a master regulator of the induction and maintenance of cellular pluripotency, and has crucial roles in early stages of differentiation. It is the only factor that cannot be substituted by other members of the same protein family to induce pluripotency. Oct4 has been shown to be an essential regulator of embryonic stem cell (ESC) pluripotency and key to the reprogramming process. OAC2 is a structural analog of OAC1. OAC2 activates both Oct4 and Nanog reporters to a similar extent as OAC1. OAC1 and its two structural analogs OAC2 and OAC3 enhances reprogramming efficiency fourfold, up to as high as 2.75%, and accelerates the appearance of iPSC colonies 3 to 4 d when used in combination with the four reprogramming factors, Oct4, Sox2, Klf4, and c-Myc.

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