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59319-72-1

中文名稱 禁止進口
英文名稱 ERYTHROMYCIN A DIHYDRATE
CAS 59319-72-1
分子式 C37H67NO13.H2O
分子量 751.945
MOL 文件 59319-72-1.mol
59319-72-1 結構式 59319-72-1 結構式

基本信息

中文別名
禁止進口
紅霉素 A 二水合物
英文別名
ERYTHROMYCIN A, DIHYDRATE VETRANAL
所屬類別
分析化學:離子色譜試劑

物理化學性質

熔點197.6 °C
形態(tài)neat

安全數(shù)據(jù)

WGK Germany2
RTECS號KF4375000

常見問題列表

生物活性
Erythromycin dihyrate 是由放線菌產(chǎn)生的大環(huán)內酯類抗生素 (antibiotic),具有廣泛的抗菌活性。Erythromycin dihyrate 通過結合細菌的 50S 核糖體亞基而起作用,并通過阻斷轉肽和/或易位反應來抑制 RNA 依賴性蛋白 (RNA-dependent protein synthesis) 的合成,而不會影響核酸的合成。
體外研究

Erythromycin dihyrate inhibits growth of P. falciparum with IC 50 and IC 90 values of 58.2 μM and 104.0 μM, respectively.

體內研究

Mice of the ddY strain began to receive Erythromycin dihyrate 7 days after inoculation of EAC cells, and CDF mice begins to receive Erythromycin dihyrate immediately after inoculation of P388 cells. Erythromycin dihyrate (gastric intubation; 0.1-50 mg/kg; 30-120 days) decreases tumor growth from the dose of 5 mg/kg, mice receiving 1-10 mg/kg of Erythromycin dihyrate survives much longer than control mice, Only 10% of mice treated with 5 mg/kg of Erythromycin dihyrate had no evidence of tumor formation on day 60, and the mice are alive even at 120 days after inoculation. However, treatment with 50 mg/kg of Erythromycin dihyrate shortens mean survival time in tumorbearing mice by 4-5 days when it compares to controls.

Animal Model: Female ddY mice at the age of 6 weeks with EAC cells or CDF mice at the age of 6 weeks with P388 cells
Dosage: 0.1 mg/kg; 0.5 mg/kg; 10 mg/kg; 30 mg/kg; 50 mg/kg
Administration: Gastric intubation; 30-120 days
Result: Decreased tumor growth and prolonged the mean survival time of mice from the dose of 5 mg/kg, however, the 50 mg/kg dosage shortens the MST in tumorbearing mice.
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