481-42-5
中文名稱
蘭雪醌
英文名稱
PLUMBAGIN
CAS
481-42-5
分子式
C11H8O3
分子量
188.18
MOL 文件
481-42-5.mol
更新日期
2025/01/07 13:19:24
481-42-5 結(jié)構(gòu)式
基本信息
中文別名
蘭雪醌礬松素
磯松素
白花丹醌
白花丹精
白花丹素
石蓯蓉萘醌
石蓯溶萘醌
白花丹醌/蘭雪醌
白花丹醌(白花丹素)
英文別名
PLUMBAGINPLUMBAGAN
plumbapin
plumbagone
NSC 236613
NSC 688284
Plumbagine
Ophioxylin
Plumbagin,95%
PLUMBAGIN(RG)
所屬類別
化學(xué)試劑：雙環(huán)化合物物理化學(xué)性質(zhì)
熔點(diǎn)76-78 °C(lit.)
沸點(diǎn)283.17°C (rough estimate)
密度1.354
折射率1.6310 (estimate)
儲(chǔ)存條件−20°C
溶解度在熱甲醇中有非常微弱的渾濁
酸度系數(shù)(pKa)6.70±0.20(Predicted)
形態(tài)晶體或結(jié)晶粉末
顏色橙色
Merck7538
穩(wěn)定性吸濕性
LogP2.450 (est)
EPA化學(xué)物質(zhì)信息1,4-Naphthalenedione, 5-hydroxy-2-methyl- (481-42-5)
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H301-H315-H319-H335
危險(xiǎn)品標(biāo)志T
危險(xiǎn)類別碼25-34-36/37/38
危險(xiǎn)品運(yùn)輸編號(hào)UN 2923 8/PG 2
WGK Germany3
RTECS號(hào)QL8500000
Hazard NoteToxic
危險(xiǎn)等級(jí)6.1(a)
包裝類別II
海關(guān)編碼29146990
毒性LD50 i.p. in mice: ~0.015 g/kg (Debray)
常見問題列表
生物活性
Plumbagin (2-Methyljuglone) 是從 Plumbago zeylanica L 中得到的萘醌類物質(zhì)，具有抗腫瘤、抗增殖活性。體外研究
Plumbagin (0, 5, 10, and 15 μM) induces apoptosis of prostate cancer cell lines, such as DU145, CWR22rv1 and LNCaP, in a dose-dependent manner.
Plumbagin (5, 20 μM) obviously inhibits the invasion of PC3, DU145, and CWR22rv1 cells.
Apoptosis Analysis
| Cell Line: | DU145, CWR22rv1, LNCaP and RWPE-1 cells |
| Concentration: | 0, 5, 10, and 15 μM |
| Incubation Time: | 24 hours |
| Result: | Dose-dependently induced apoptosis of DU145, CWR22rv1 and LNCaP, but showed no effect on RWPE-1 cells at up to 20 μM. |
體內(nèi)研究
Plumbagin (2 mg/kg, i.p., five days a week for 11 weeks) inhibits the growth of tumor in male athymic nude mice.
Plumbagin (2 mg/kg, i.p., five days a week for 11 weeks) inhibits expression of PKCε, suppresses JAK-2 and Stat3 phosphorylation, and activates Stat3, PCNA, VEGF and MMP-9 in mice.
| Animal Model: | Male athymic nude mice bearing DU145 cells |
| Dosage: | 2 mg/kg |
| Administration: | I.P. after 3 days post cell implantation, five days a week. |
| Result: | Delayed tumor growth by 3 weeks, and reduced tumor weight and volume in mice. |