4673-26-1
4673-26-1 結(jié)構(gòu)式
基本信息
二亞苯基碘氯化物
氯化二亞苯基碘嗡
氯化二亞苯基碘鎓
二亞苯基碘鎓氯化物
DPI CHLORIDE
DIBENZIODOLIUM CHLORIDE
DIPHENYLENEIODONIUM CHLORIDE
Dibenz[b,d]iodoliuM Chloride
Dibenziodolium chloride, DPI
Diphenyleneiodonium chloride, 97+%
DiphenyleneiodoniuM chloride, 97+% 25MG
[1,1'-BIPHENYL]-2,2'-DIYLIODONIUM CHLORIDE
Diphenyleneiodonium chlorideDibenziodolium chloride
物理化學(xué)性質(zhì)
常見問題列表
| Target | Value |
|
NADPH oxidase
() |
DPI抑制NADPH oxidase、一氧化氮合成酶、黃嘌呤氧化酶和NADPH細(xì)胞色素P450氧化還原酶的活性。飛摩爾級別的DPI即可通過抑制ERK調(diào)節(jié)的PHOX活性、抑制小膠質(zhì)細(xì)胞的激活，發(fā)揮其抗炎活性和神經(jīng)保護(hù)作用。DPI常被用于抑制由多種黃素酶介導(dǎo)的ROS生成。NADPH, NADP+, and 2'5'-ADP可阻止DPI的抑制活性。對ARPE-19細(xì)胞處理以DPI可引起劑量依賴性和時間依賴性的生長抑制，誘導(dǎo)DNA斷裂和促凋亡因子Bax的蛋白水平。除此之外，DPI還可顯著地誘導(dǎo)p53的表達(dá)和其磷酸化，在DNA損傷或無法修復(fù)的DNA周期阻滯中，誘導(dǎo)促凋亡基因的表達(dá)。
Intraplantar injection of 2 mM Diphenyleneiodonium chloride to the hindpaw causes licking or biting behavior. Diphenyleneiodonium chloride treatment immediately or 24 h after lipopolysaccharide (LPS) injection significantly attenuates the LPS-induced loss of O4 positive cells. Treatment with Diphenyleneiodonium chloride either immediately or 24 h after LPS injection significantly ameliorates the LPS-induced disorganization of the white matter nerve fibers. However, treatment with DPI 48 h after LPS injection does not appear to correct the LPS-induced white matter damage. DPI treatment either immediately or 24 h after LPS injection significantly reduces the accumulation of both gp91phox and p67phox in the membrane fraction.