37413-91-5
中文名稱
21-羥基孕甾-1,4,9(11),16-四烯-3,20-二酮-21-醋酸酯
英文名稱
3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate
CAS
37413-91-5
分子式
C23H26O4
分子量
366.45
MOL 文件
37413-91-5.mol
更新日期
2025/01/14 09:15:49
37413-91-5 結(jié)構(gòu)式
基本信息
中文別名
醋酸四烯物潑尼松雜質(zhì)12
醋酸四烯物(3TR)
布地奈德雜質(zhì)對照品6
16-四烯-3,20-二酮-21-醋酸酯
21-乙酰氧基孕甾-1,4,9(11),16-四烯-3,20-酮
21-羥基孕甾-1,4,9(11),16-四烯-3,20-二酮-21-醋酸酯
21-羥基孕甾-1,4,9(11),16-四烯-3,20-二酮-21-醋酸酯 100G
2-((8S,10S,13S,14S)-10,13-二甲基-3-氧代-6,7,8,10,12,13,14,15-八氫-3H-環(huán)戊二烯并[A]菲-17-基)-2-氧代乙基 乙酸酯
英文別名
37413-91-516-tetraen-21-yl
Tetraene acetate[3TR]
Prednisone Impurity 12
Acetate tetraene Matter
Tetraen-acetic acid complex
Pregna-1,4,9(11),16-tetraen
21-Hydroxy-1,4,9(11)-tetraene 21-acetate
21-Acetoxypregna-1,4,9(11),16-tetrene-3,20-dione
21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione
物理化學(xué)性質(zhì)
熔點(diǎn)173-175°C
沸點(diǎn)534.6±50.0 °C(Predicted)
密度1.21±0.1 g/cm3(Predicted)
儲存條件Refrigerator
常見問題列表
用途
醋酸四烯物(21-羥基孕甾-1,4,9(11),16-四烯-3,20-二酮-21-醋酸酯,3TR)是合成曲安奈德、地塞米松、布地奈德等甾體藥物的重要中間體生物活性
21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione 是 delta 9,11 類固醇類合成的中間體 (intermediate)，如 Vamorolone?(HY-109017)。delta 9,11 steroids 是糖皮質(zhì)激素的修飾后的產(chǎn)物，具有抗炎 (anti-inflammatory) 特性。delta 9,11 類固醇類可以用作保護(hù)細(xì)胞損傷(脂質(zhì)過氧化)和抑制新生血管的試劑。體外研究
Δ9,11 derivatives are designed and developed to stably incorporate into cell membranes and inhibit lipid peroxidation without glucocorticoid or mineralocorticoid activities, thus avoiding side effects associated with traditional corticosteroids. VBP15 acts as a lead compound due to potent NF-κB inhibition and GR translocation similar to prednisone and dexamethasone, lack of transactivation properties, and good bioavailability.