352693-80-2
中文名稱
7-((2,3-二氯苯基)(吡啶-2-基氨基)甲基)喹啉-8-醇
英文名稱
7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol
CAS
352693-80-2
分子式
C21H15Cl2N3O
分子量
396.269
MOL 文件
352693-80-2.mol
更新日期
2023/11/10 17:19:26
352693-80-2 結(jié)構(gòu)式
基本信息
中文別名
7-((2,3-二氯苯基)(吡啶-2-基氨基)甲基)喹啉-8-醇 英文別名
7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol物理化學(xué)性質(zhì)
儲(chǔ)存條件4°C, protect from light
溶解度DMSO : 62.5 mg/mL (157.72 mM; ultrasonic and warming and heat to 60°C)
形態(tài)Solid
顏色White to off-white
應(yīng)用領(lǐng)域
用途一
MMRi62 is an MDM4-degrader and apoptosis inducer in leukemia cells. MMRi62 targets MDM4 for degradation and induces leukemic cell apoptosis regardless of p53 status. MMRi62 effectively induced apoptosis in p53 mutant, multidrug-resistant leukemia cells and patient samples in addition to p53 wild-type cells. In contrast, MMRi67 as a RING heterodimer disruptor and an enzymatic inhibitor of the MDM2-MDM4 E3 complex lacked MDM4-degrader activity and failed to induce apoptosis in these cells.7-((2,3-二氯苯基)(吡啶-2-基氨基)甲基)喹啉-8-醇價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/02/08 | HY-148409 | 7-((2,3-二氯苯基)(吡啶-2-基氨基)甲基)喹啉-8-醇 MMRi62 | 352693-80-2 | 1 mg | 291元 |
| 2025/02/08 | HY-148409 | 7-((2,3-二氯苯基)(吡啶-2-基氨基)甲基)喹啉-8-醇 MMRi62 | 352693-80-2 | 10 mM * 1 mLin DMSO | 567元 |
| 2025/02/08 | HY-148409 | 7-((2,3-二氯苯基)(吡啶-2-基氨基)甲基)喹啉-8-醇 MMRi62 | 352693-80-2 | 5 mg | 650元 |