34981-25-4
34981-25-4 結(jié)構(gòu)式
基本信息
中文別名
次苦參素次苦參黃素
英文別名
Kuraridine2,2',4,4'-Tetrahydroxy-6'-methoxy-3'-(5-methyl-2-isopropenylhex-4-enyl)chalcone
2-Propen-1-one, 1-[2,4-dihydroxy-6-methoxy-3-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]phenyl]-3-(2,4-dihydroxyphenyl)-, (2E)-
物理化學(xué)性質(zhì)
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
形態(tài)粉末
顏色黃色固體
次苦參素價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/02/08 | HY-121381 | 次苦參素 Kuraridine | 34981-25-4 | 1 mg | 3500元 |
常見問題列表
生物活性
Kuraridine 是一種從苦參根中得到的酮醇提取物。Kuraridine 對(duì) cGMP 特異性磷酸二酯酶 5 型 (PDE5) 有抑制作用，IC50 值為?0.64 μM。靶點(diǎn)
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PDE5 0.64 μM (IC 50 ) |
體外研究
Kuraridine shows potent inhibitory activity (IC 50 =0.64 μM) against cGMP PDE5 with 2.0- and 12.9-fold selectivity over PDE3 and PDE4, respectively.Kuraridine induces pronounced chloride inward currents in the absence of GABA. Thecurrents does not exceed 10% of the maximal I GABA induced by a saturating GABA concentration (1 mM).Kuraridine induces a concentration–response curves for I GABA enhancement (EC 50 =4.0±2.4 μM) in Xenopus oocytes expressing GABA A receptors composed of?α1, β2, and?γ2S?subunits.