34334-69-5
中文名稱
條葉薊素
英文名稱
6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
CAS
34334-69-5
分子式
C17H14O7
分子量
330.29
MOL 文件
34334-69-5.mol
更新日期
2024/09/18 11:49:24
34334-69-5 結(jié)構(gòu)式
基本信息
中文別名
中國薊醇條葉薊素
英文別名
CIRSILIOLCrisiliol
Cirsiliol >=95% (HPLC)
3'-Hydroxy-6-methoxygenkwanin
3',4',5-Trihydroxy-6,7-dimethoxy
6-Methoxyluteolin 7-methyl ether
6-Hydroxyluteolin-6,7-dimethyl ether
6,7-DIMETHOXY-5,3',4'-TRIHYDROXYFLAVONE
6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
6,7-DIMETHOXY-3,4'',5-TRIHYDROXYFLAVONE 95+%
所屬類別
天然產(chǎn)物：黃酮類化合物物理化學(xué)性質(zhì)
熔點280-281.5℃ (methanol )
沸點616.1±55.0 °C(Predicted)
密度1.483±0.06 g/cm3(Predicted)
儲存條件2-8°C
溶解度Acetone: soluble; Chloroform: soluble; DMSO: soluble
酸度系數(shù)(pKa)6.31±0.40(Predicted)
形態(tài)粉末
顏色白色至米色
常見問題列表
生物活性
Cirsiliol是有效和選擇性的5-脂氧合酶 (5-lipoxygenase) 抑制劑，并且是競爭性低親和力的苯二氮卓受體配體。靶點
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5-Lipoxygenase
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體外研究
In concentrations from 0.01 to 300 μM, cirsiliol causes concentration-dependent relaxation of rat isolated ileum. Cirsiliol may inhibit Ca 2+ influx but stimulates Ca 2+ release from intracellular stores. Treatment with rhamnetin or cirsiliol reduces the proliferation of NSCLC cells through the suppression of radiation-induced Notch-1 expression.
體內(nèi)研究
In xenograft mouse model, tumor volume is significantly reduced by combinational treatment with irradiation and rhamnetin or cirsiliol compared with irradiation alone.