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33985-68-1

中文名稱 3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole)
英文名稱 3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole)
CAS 33985-68-1
分子式 C24H20N2O
分子量 352.43
MOL 文件 33985-68-1.mol
更新日期 2025/01/23 13:36:08
33985-68-1 結(jié)構(gòu)式 33985-68-1 結(jié)構(gòu)式

基本信息

中文別名
化合物DIM-C-PPHOCH3
英文別名
C-DIM5
DIM-C-pPhOCH3
DIM-C-pPhOCH3(C-DIM5)
DIM-C-pPhOCH3 >=98% (HPLC)
Bis(1H-indol-3-yl)(4-methoxyphenyl)]methane
1,1-bis(3′-Indolyl)-1-(p-methoxyphenyl)methane
3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole)
1H-Indole, 3,3'-[(4-methoxyphenyl)methylene]bis-

物理化學(xué)性質(zhì)

熔點187-189 °C
沸點592.7±50.0 °C(Predicted)
密度1.251±0.06 g/cm3(Predicted)
儲存條件2-8°C
溶解度二甲基亞砜:≥30mg/mL
酸度系數(shù)(pKa)16.63±0.30(Predicted)
形態(tài)粉末
顏色灰白色至淡黃色

安全數(shù)據(jù)

WGK Germany3
3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole)價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2025/02/08HY-111492DIM-C-pPhOCH333985-68-11 mg320元
2025/02/08HY-1114923,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole)
DIM-C-pPhOCH3
33985-68-110mM * 1mLin DMSO620元
2025/02/08HY-1114923,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole)
DIM-C-pPhOCH3
33985-68-15mg800元

常見問題列表

生物活性
C-DIM5 (DIM-C-pPhOCH3) 是一種孤兒核受體 Nur77 (Nerve growth factor-induced Bα (NGFI-Bα)/nuclear receptor 4A1 (NR4A1)) 的激動劑。C-DIM5 (DIM-C-pPhOCH3) 可在RKO結(jié)腸癌細胞中降低存活率并誘導(dǎo)凋亡。
靶點
TargetValue
Nur77
()
體外研究

DIM-C-pPhOCH 3 decreases survival and induces apoptosis in RKO colon cancer cells, and this is accompanied by induction of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) protein. DIM-C-pPhOCH 3 also induces Nur77-independent apoptosis. DIM-C-pPhOCH 3 (10 μM) inhibits cell growth after treatment for 24, 48, or 72 h, and the maximum inhibitory response is observed after 72 h, where there is considerable cell detachment and dead cells. The growth-inhibitory effects observed for DIM-C-pPhOCH 3 after 72 h are also accompanied by several markers of apoptosis, including PARP cleavage and cleavage of caspase-3, caspase-9, and caspase-8. PARP cleavage is also observed after treatment of RKO cells for 48 h with DIM-C-pPhOCH 3 .

體內(nèi)研究

DIM-C-pPhOCH 3 (25 mg/kg/d) also inhibits tumor growth in athymic nude mice bearing RKO cell xenografts. The effects of DIM-C-pPhOCH 3 (25 mg/kg/d) on colon tumor growth are also investigated in athymic nude mice bearing RKO cell xenografts. Treatment with the DIM-C-pPhOCH 3 significantly decreases tumor volumes and final tumor weights compared with corn oil controls.

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