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264275-77-6

中文名稱 L-ALANINE, N-[2,6-DICHLORO-4-[[[(3-HYDROXYPHENYL)METHYL]AMINO]CARBONYL]BENZOYL]-3-[(3,5-DIHYDROXYBEN
英文名稱 L-Alanine, N-[2,6-dichloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(3,5-dihydroxybenzoyl)amino]-
CAS 264275-77-6
分子式 C25H21Cl2N3O8
分子量 562.36
MOL 文件 264275-77-6.mol
264275-77-6 結(jié)構(gòu)式 264275-77-6 結(jié)構(gòu)式

基本信息

中文別名
L-ALANINE, N-[2,6-DICHLORO-4-[[[(3-HYDROXYPHENYL)METHYL]AMINO]CARBONYL]BENZOYL]-3-[(3,5-DIHYDROXYBEN
英文別名
XVA143
L-Alanine, N-[2,6-dichloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(3,5-dihydroxybenzoyl)amino]-

應(yīng)用領(lǐng)域

用途一
XVA143 is a α/β I allosteric inhibitor of the integrin leucocyte function-associated antigen-1 (αLβ2, LFA-1) which plays crucial roles in T cell adhesion, migration and immunological synapse (IS) formation. Consequently, αLβ2 is an important therapeutic target in autoimmunity.
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