2410512-38-6
中文名稱(chēng)
JQKD-82
英文名稱(chēng)
4-Pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-, 2,4-bis(1-methylethoxy)phenyl ester
CAS
2410512-38-6
分子式
C27H40N4O5
分子量
500.64
MOL 文件
2410512-38-6.mol
更新日期
2025/02/05 11:21:30
2410512-38-6 結(jié)構(gòu)式
基本信息
中文別名
PCK-82JQKD-82
英文別名
JADA82JQKD-82
4-Pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-, 2,4-bis(1-methylethoxy)phenyl ester
應(yīng)用領(lǐng)域
用途一
JQKD82, also known as PCK82, is a cell-permeable and selective KDM5 inhibitor (MM.1S cells, IC50 = 0.42 uM). JQKD82 increases histone H3K4me3 but paradoxically inhibits downstream MYC-driven transcriptional output in vitro and in vivo. JQKD82 is a useful tool compound to block KDM5A function as a potential therapeutic strategy for MM. QKD82 is a more stable ester of KDM5-C49 that is able to deliver the active molecule KDM5-C49 to cells more efficiently