22494-47-9
中文名稱
氯丁扎利
英文名稱
clobuzarit
CAS
22494-47-9
分子式
C17H17ClO3
分子量
304.77
MOL 文件
22494-47-9.mol
更新日期
2023/03/17 20:03:06
22494-47-9 結(jié)構(gòu)式
基本信息
中文別名
氯丁扎利 英文別名
ClozicICI-55897
clobuzarit
2-[(4'-Chloro-4-biphenylyl)methoxy]-2-methylpropionic acid
2-[[4'-Chloro(1,1'-biphenyl)-4-yl]methoxy]-2-methylpropionic acid
2-[(4'-Chloro[1,1'-biphenyl]-4-yl)methoxy]-2-methylpropanoic acid
Propanoic acid, 2-[(4'-chloro[1,1'-biphenyl]-4-yl)methoxy]-2-methyl-
常見(jiàn)問(wèn)題列表
生物活性
Clozic 是一種潛在的抗關(guān)節(jié)炎藥物。體外研究
Clozic is a potential anti-arthritic agent. Concentrations of Clozic greater than 50 μM cause a dose-dependent decrease in the amount of matrix protein synthesized by RHMC cell cultures. Inhibition of RHMC cell culture growth by Clozic occurs in a dose-dependent manner. The anti-proliferative effect of Clozic on RHMC cell growth is reversible. Lactate dehydrogenase (LDH) levels in media taken from RHMC cell cultures exposed to 500 μM Clozic for 3 days do not significantly differ from LDH levels in control cell culture media.