221287-83-8
221287-83-8 結(jié)構(gòu)式
基本信息
中文別名
脫乙?；咸擒账徕c鹽脫乙酰基-D4葡糖苷酸
英文別名
Tizoxanide-d4 GlucuronideTIZOXANIDE GLUCURONIDE, SODIUM SALT
2-[[(5-Nitro-2-thiazolyl)aMino]carbonyl]phenyl β-D-Glucopyranosiduronic Acid
2-[[(5-Nitro-2-thiazolyl)amino]carbonyl]phenyl -D-Glucopyranosiduronic Acid Monosodium Salt
常見(jiàn)問(wèn)題列表
生物活性
Tizoxanide glucuronide-D4 是氘標(biāo)記的 Tizoxanide glucuronide。Tizoxanide glucuronide 是硝唑奈德 (HY-B0217) 的代謝物 (metabolite)，具有細(xì)胞穿透性，可抑制寄生蟲(chóng) (parasite) C. parvum 的無(wú)性和有性發(fā)育階段。靶點(diǎn)
IC50: parasite
體外研究
Tizoxanide glucuronide (1-50 μg/ml; 46 hours) has effects on parasite development of Cryptosporidium parvum in HCT-8 cells. It exhibits MIC 50 values of 2.2?μg/ml; 45.2 μg/ml; 11.7?μg/ml and 2.8 μg/ml in a sexual and sexual stages, sporozoite stage, asexual stages and sexual stages, respectively.