220643-77-6
中文名稱
P-MPPI MONOHYDROCHLORIDE
英文名稱
P-MPPI MONOHYDROCHLORIDE
CAS
220643-77-6
分子式
C25H27IN4O2HCl
MOL 文件
220643-77-6.mol
更新日期
2023/02/22 11:54:00
220643-77-6 結構式
基本信息
中文別名
化合物P-MPPI HYDROCHLORIDE 英文別名
P-MPPI MONOHYDROCHLORIDE4-iodo-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylbenzamide:hydrochloride
4-iodo-n-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl)benzamide monohydrochloride
Benzamide,4-iodo-N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-,monohydrochloride
4-iodo-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)benzamide hydrochloride (1:1)
物理化學性質(zhì)
儲存條件Inert atmosphere,Room Temperature
溶解度DMSO: 17.86 mg/mL (30.85 mM)
形態(tài)Solid
顏色White to off-white
P-MPPI MONOHYDROCHLORIDE價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2023/01/06 | S0880 | P-MPPI MONOHYDROCHLORIDE p-MPPI hydrochloride | 220643-77-6 | 5mg | 2841.93元 |
| 2023/01/06 | S0880 | P-MPPI MONOHYDROCHLORIDE p-MPPI hydrochloride | 220643-77-6 | 25mg | 8591.31元 |
常見問題列表
生物活性
p-MPPI hydrochloride 是一種選擇性的，具有高親和力的 5-HT1A 受體拮抗劑。p-MPPI hydrochloride 能穿過血腦屏障，具有明顯的抗抑郁和抗焦慮作用。靶點
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5-HT 1A Receptor
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體外研究
p-MPPI hydrochloride has no agonist activity in both in vitro and in vivo tests of pre- and post-synaptic 5-HT1A receptor activity.
體內(nèi)研究
p-MPPI hydrochloride (0.5-4.5 mg/kg; i.p.) shows anxiolytic-like profile in the murine elevated plus-maze.
| Animal Model: | Adult male Swiss Webster mice (aged 8-9 weeks) |
| Dosage: | 0.5, 1.5, 4.5 mg/kg |
| Administration: | i.p. |
| Result: | Produced a significant and dose-related anxiolytic profile on both conventional (open arm avoidance) and ethological (risk assessment) measures. |