2173232-79-4
2173232-79-4 結構式
物理化學性質
沸點386.2±42.0 °C(Predicted)
密度1.436±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO : 6 mg/mL (23.23 mM);Water : < 0.1 mg/mL (insoluble)
酸度系數(pKa)3.04±0.20(Predicted)
形態(tài)Solid
顏色Pink to red
2173232-79-4價格(試劑級)
| 報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
| 2025/02/08 | HY-101035 | LOM612 | 2173232-79-4 | 1 mg | 1590元 |
| 2025/02/08 | HY-101035 | 2173232-79-4 LOM612 | 2173232-79-4 | 5mg | 3500元 |
| 2025/02/08 | HY-101035 | 2173232-79-4 LOM612 | 2173232-79-4 | 10mM * 1mLin DMSO | 3850元 |
常見問題列表
生物活性
LOM612 有效對 FOXO 胞質-胞核穿梭進行定位，在 U2fox RELOC 細胞中 EC50 值為 1.5 μM。靶點
EC50: 1.5 μM (FOXO, in U2fox RELOC cells)
體外研究
LOM612 potently activates nuclear translocation of FOXO with an EC 50 value of 1.5 μM, and this effect is independent of CRM-1. LOM612 effectively induces translocation of endogenous FOXO3a and FOXO1, and increases the expression of the FOXO target genes p27 and FasL. LOM612 shows no effect on the nuclear export of endogenous NFKB2 transcription factor in U2OS cells. LOM612 is cytotoxic to HepG2 cells, with an IC 50 value of 0.64 μM, and does not sensitize non-cancer THLE2 cells (IC 50 , 2.76 μM).