209969-60-8
中文名稱
化合物 T27269
英文名稱
2H-1-Benzopyran-2-one, 7-methoxy-6-[3-[4-(2-methoxyphenyl)-1-piperazinyl]propoxy]-3,4-dimethyl-, hydrochloride (1:1)
CAS
209969-60-8
分子式
C26H33ClN2O5
分子量
489.01
MOL 文件
209969-60-8.mol
209969-60-8 結構式
基本信息
中文別名
化合物 T27269 英文別名
KA672KA 672
KA-672 HCl
Ensaculin HCl
Anseculin Hydrochloride
2H-1-Benzopyran-2-one, 7-methoxy-6-[3-[4-(2-methoxyphenyl)-1-piperazinyl]propoxy]-3,4-dimethyl-, hydrochloride (1:1)
應用領域
用途一
Ensaculin, also known as KA-672, is a NMDA antagonist and a 5HT1A agonist potentially for the treatment of Alzheimer's disease (AD). Ensaculin showed memory-enhancing effects in paradigms of passive and conditioned avoidance in both normal and artificially amnesic rodents. It exhibited neuroprotective activities in an NMDA toxicity model and neurotrophic effects in primary cultured rat brain cells. In receptor-binding studies, ensaculin was found to have high affinities to serotonergic 5-HT(1A) and 5-HT(7) receptors, adrenergic alpha(1), and dopaminergic D(2) and D(3) receptors.