2070015-13-1
中文名稱
ML241 (hydrochloride)
英文名稱
ML241 (hydrochloride)
CAS
2070015-13-1
分子式
C23H25ClN4O
分子量
408.93
MOL 文件
2070015-13-1.mol
更新日期
2024/11/15 18:20:30
![2070015-13-1 結構式](/CAS/20211123/GIF/2070015-13-1.gif)
ML241 (hydrochloride)價格(試劑級)
報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
2025/02/08 | HY-19797A | ML241 (hydrochloride) ML241 hydrochloride | 2070015-13-1 | 5mg | 600元 |
2025/02/08 | HY-19797A | ML241 (hydrochloride) ML241 hydrochloride | 2070015-13-1 | 10mM * 1mLin DMSO | 660元 |
2025/02/08 | HY-19797A | ML241 (hydrochloride) ML241 hydrochloride | 2070015-13-1 | 10mg | 960元 |
常見問題列表
生物活性
ML241 hydrochloride 是一種 p97 的有效選擇性抑制劑,對 p97 ATPase 和 UbG76V–GFP 的IC50值分別為0.11 μM和3.5 μM。靶點
Target | Value |
p97 ATPase
(Cell-free assay) | 0.11 μM |
Ub
(Cell-free assay) | 3.5 μM |
體外研究
ML241 hydrochloride is a potent p97 inhibitor, inhibiting p97 ATPase with IC 50 values of 100 nM. ML241 inhibits p97 competitively with respect to ATP with a K i values of 0.35 μM. ML241 (20 μM) shows no obvious inhibition of the appr 170 kinases tested. ML241 stabilizes Ub G76V -GFP with IC 50 of 3.5 μM. ML241 is cytotoxic to HCT15 and SW403 cells, with GI 50 s of 53 and 33 μM after treatment for 24 h, and 13 and 12 μM after treatment for 72 h, respectively.