199596-24-2
中文名稱
(Z)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE
英文名稱
JIB-04 (NSC 693627) -Z
CAS
199596-24-2
分子式
C17H13ClN4
分子量
308.76
MOL 文件
199596-24-2.mol
更新日期
2023/03/20 15:41:19
199596-24-2 結(jié)構(gòu)式
基本信息
中文別名
化合物Z-JIB-04 英文別名
Z-JIB-04JIB-04 (Z)
JIB-04 Z-isomer
NSC 693627
Z-JIB-04
Z-JIB-04 (NSC 693627)
JIB-04 (NSC 693627) -Z
5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine
(Z)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE
(Z)-1-(5-Chloropyridin-2-yl)-2-(phenyl(pyridin-2-yl)methylene)hydrazine
Methanone, phenyl-2-pyridinyl-, 2-(5-chloro-2-pyridinyl)hydrazone, (Z,Z)-
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)472.9±55.0 °C(Predicted)
密度1.24±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 6 mg/mL (19.43 mM)
酸度系數(shù)(pKa)11.00±0.10(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
(Z)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-107842 | (Z)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE (Z)-JIB-04 | 199596-24-2 | 5mg | 600元 |
| 2024/11/08 | HY-107842 | (Z)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE (Z)-JIB-04 | 199596-24-2 | 10mg | 960元 |
| 2024/11/08 | HY-107842 | (Z)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE (Z)-JIB-04 | 199596-24-2 | 50mg | 3000元 |
常見問(wèn)題列表
生物活性
Z-JIB-04 (NSC 693627, JIB-04 Z-isomer)是JIB-04的異構(gòu)體。JIB-04 是一種泛選擇性的 Jumonji histone demethylase 抑制劑，對(duì)于JARID1A、JMJD2E、JMJD3、JMJD2A、JMJD2B、JMJD2C和JMJD2D的IC50值分別為230 nM、340 nM、855 nM、445 nM、435 nM、1100 nM和290 nM。靶點(diǎn)
| Target | Value |
|
JARID1A
(Cell-free assay) | 230 nM |
|
JMJD2D
(Cell-free assay) | 290 nM |
|
JMJD2E
(Cell-free assay) | 340 nM |
|
JMJD2B
(Cell-free assay) | 435 nM |
|
JMJD2A
(Cell-free assay) | 445 nM |
體外研究
JIB-04 inhibits the demethylase activity of Jumonji enzymes in vitro and in cells, without affecting other α-ketoglutarate dependent hydroxylases or histone modifying enzymes .